Influnceing Factors sV cO Hr Flashcards
what is the formula for cardiac output?
heart rate times stroke volume equals cardiac output
HR(SV)= CO
what is the formula for stroke volume?
EDV- ESV= SV
change heart rate alter activity of nodal cells often work by autonomic nervous system or hormones
chronotropic agents
chronotropic agent acts to alter activity of nodal cells of via?
autonomic nervous system or hormones
a positive chronotropic agent that increases the number of B1 Adrena genic receptors on nodal cells?
thyroid hormone
positive chronotropic agent that inhibits breakdown of camp
caffeine
positive chronotropic agent that increases release of norepinephrine
nicotine
positive chronotropic agent that inhibits reuptake of norepinephrine
cocaine
what factors influence heart rate?
1) chronotropic agents
2) autonomic reflexes
what protects the heart from overfilling?
Bainbridge reflex
baroreceptors in atrial walls are stimulated by venous return, increase nerve impulses to cardio accelera Tory Center comma increased excitation of sympathetic
Bainbridge / atrial reflex
what factors influence stroke volume?
venous return inotropic agents and afterload
venous return
intropic agents
afterload
increase in end-diastolic volume, greater stretch on atrial wall equals more optimal overlap of thick and thin filaments
Frank Starling law influences stroke volume maintains bounce ventricular output
maintains balance ventricular output
Frank Starling law
volume of blood returns to the heart effects?
stroke volume
stroke volume directly affects
cardiac output
venous return stroke volume heart rate all effect?
cardiac output
amount of blood pumped by one single ventricle in one minute?
cardiac output
parasympathetic axons released acetylcholine that binds to M2 muscarinic receptors this opens potassium channels causing hyperpolarization which causes?
is hyperpolarization causes a longer time to reach threshold.
slows heart rate - negative chronotropic agents
what is an example of a negative chronotropic agent?
beta blockers
inotropic agents affect?
alter contractility and change stroke volume
generally inotropic agents Ultra contractility due to changes in?
calcium available in sarcoplasm
positive inotropic agents increase available calcium via?
EPI and NE work by a beta 1 receptors to increase calcium
thyroid hormone increases # beta 1 receptors
electrolyte imbalances and certain drugs that block channels decrease available calcium best lowering contractility these are referred to as?
negative inotrope agents