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ACVP Phase II Exam - Anatomic Pathology > IHC > Flashcards

IHC Flashcards

1
Q

GFAP

A

Cytoplasmic and cell processes of astrocytes

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2
Q

Nestin

A

intermediate filament in embryonic nerve cells and hair follicle stem cells (can differentiate into multiple types of cells), proliferating new endothelial cells. Cytoplasm.

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3
Q

Synaptophysin

A

Neuroendocrine: Adrenal medulla, neuronal cells, neuroendocrine cells, pineal gland. Membrane and cytoplasm (integral membrane protein and pre-synaptic vesicles)

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4
Q

Vimentin

A

intermediate filament of mesenchymal cells; cytoplasm

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5
Q

Neurofilament

A

Neurons; cytoskeletal component of axons and dendrites

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6
Q

SOX-10

A

Transcription factor; neural crest derived tissues; expressed by melanocytes, mammary myoepithelial cells and Schwann cells. Melanoma & neural crest marker!

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7
Q

TTF-1

A

Thyroid Transcription Factor 1; found in the nucleus only! Thyroid, lung and diencephalic brain (thalamus/hypothalamus/pineal/pituitary) structures.

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8
Q

Chromogranin

A

secretory vesicles of neuroendocrine cells; Adrenal medulla (chromaffin cells), heart AV node, pancreas (islets), parathyroid (chief cells), thyroid (C cells)

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9
Q

Desmin

A

Intermediate filament in cardiac, smooth and skeletal muscle (GISTs are negative)

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10
Q

CD31/PECAM

A

PECAM; Membranous expression! Endothelial cells at cell junctions, megakaryocytes, pericytes, platelets, brown fat, trophoblasts, fibroblasts, spermatozoa, surface of platelets, monocytes, neutrophils and some types of T cells. key role in leukocyte trafficking across endothelium

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11
Q

Calponin

A

Actin-filament associated protein; Smooth muscle, myoepithelial cells, myofibroblasts, keratinocytes and nerve fibers

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12
Q

Alkaline Phosphatase

A

sarcoplasm of regenerating myofibers and cytoplasm of arteriole endothelial cells (not capillaries)

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13
Q

CD79a

A

B cells / B cell origin (with CD20) including plasma cells. May be positive when CD20 is negative.

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14
Q

CD20

A

B cells (not plasma cells)

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15
Q

CD45

A

also called leukocyte common antigen; NUCLEATED HEMATOPOIETIC CELLS (so not RBC’s, megakaryocytes or PLT’s).

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16
Q

CD18

A

leukocyte adhesion protein (deficiency leads to LAD); Neutrophils, macrophages, monocytes, NK cells and basophils

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17
Q

CD3

A

Thymocytes, peripheral T cells, NK cells (early cytoplasmic staining, then membranous)

18
Q

c-KIT

A

AKA CD 117; proto-oncogene activated in GISTs and Mast Cell Tumors; cytoplasmic expression. Also found in interstitial cells of Cajal, hematopoietic progenitor cells, melanocytes, embryonic/fetal brain, endothelium, gonads, breast epithelium, germ cells.

19
Q

S-100

A

show nerve sheath involvement (i.e Schwann cell) or melanocytic origin; neurons, myoepithelial cells, adipocytes, langerhans/ tissue and interdigitating dendritic cells, chondrocytes and notochord

20
Q

PNL-2

A

melanocytes; cytoplasm

21
Q

Melan-A

A

AKA MART1; cytoplasm. Anything that forms melanosomes.

22
Q

DOG-1

A

GISTs only. Discovered On Gists 1. Membrane & cytoplasm.

23
Q

Ki67

A

proliferation index during G1, S, G2 and M phases of cell cycle. Not found in G0 and early G1. Nuclear stain is the only one that “counts”.

24
Q

CK AE1/AE3

A

Epithelial cells and trophoblasts; Detects CK1-8, 10, 14-16 and 19

25
Q

CK 34BE12

A

Squamous, transitional and some ductal epithelium

26
Q

CK5/6

A

Mammary myoepithelial cells, cornea, mesothelium, basal epithelium

27
Q

CK 7

A

Glandular and transitional epithelium

28
Q

CK 8/18

A

Carcinomas of epithelial origin and mesotheliomas

29
Q

CK 20

A

Gastric, intestinal, urothelial epithelium and Merkel cells

30
Q

Doublecortin

A

neurons

31
Q

E-cadherin

A

decreased in carcinoma

32
Q

Argyrophilic Nucleolar Organizer Region (AgNOR)

A

Proliferation marker; increased nucleolar silver stained dots increases the potential for malignancy

33
Q

Calretinin

A

Adipocytes, mesothelial cells, endometrial stroma, Leydig cells, mast cells, nerves, ovarian theca cells, Sertoli cells

34
Q

HMB-45

A

Melanocytes

35
Q

Iba-1

A

Macrophages/histiocytes/microglia

36
Q

Inhibin

A

Sertoli cells, granulosa cells, prostate, brain, adrenal gland

37
Q

Laminin

A

Basement membrane

38
Q

Tyrosinase-related protein-1 (TRP1) and 2 (TRP2)

A

melanocytes

39
Q

Uroplakin I, II, III

A

urothelium

40
Q

WT-1 (Wilms tumor)

A

Nephroblastoma

ACVP Phase II Exam - Anatomic Pathology (25 decks)

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