Autoimmune Skin Diseases Flashcards
What is the group of toxins in impetigo?
Staphylococcal exfoliative toxins from Staph. intermedius
The primary targets in pemphigus foliaceous are?
Desmocollin-1 (major) and Desmoglein 1 (minor), a component of the desmosomes in the superficial epidermis of haired skin and follicles
What is the histologic lesion of toxic epidermial necrolysis?
apoptotic cells in all layers of the epidermis WITHOUT ASSOCIATED DERMAL OR EPIDERMAL INFLAMMATION
What is the most common canine breed associated with mucous membrane pemphigoid?
German Shepherd dog
What is the major immune target in pemphigus vulgaris?
Desmoglein 3. PV affects mucuous membranes and oral mucosa only.
Which disease has the histologic feature of suprabasilar epidermal spongiosis & vacuolation, formation of vesicles, bullae, and suprabasilar acantholysis and intraepidermal clefts between the stratum basale and stratum spinosum?
pemphigus
The feature of tombstone cells, a row of basilar cells that remain attached to the basement membrane at the base of the cleft, is a feature of what disease?
pemphigus
What is the most common autoimmune skin disease in the dog?
cutaneous lupus
Pemphigus reflects mainly a Type II hypersensitivity while lupus reflects mainly a Type _______ hypersensitivity
Type III d/t antigen-antibody complexes
SLE is usually ANA (positive/negative) while CLE is usually ANA (positive/negative)
SLE is ANA positive, CLE is ANA negative
A lichenoid dermatitis at the dermal-epidermal junction along with basal cell hydropic degeneration and Civatte bodies (apoptotic basal cells) are features of which autoimmune skin disease?
CLE
What is the difference between erythema multiforme and TEN?
EM has both apoptotic cells in all layers of the epidermis and dermal inflammation
