hypertension Flashcards

1
Q

what is the increase risk of mortality with each 2mmhg bp

A

7% heart disease

10% stroke

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2
Q

what proportion of the uk population have hypertension

A

25%

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3
Q

what proportion of people over 60 have hypertension

A

50%

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4
Q

what is stage one hypertension

A
clinic = 140/90
ABPM = 135/85
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5
Q

what is stage 2 hypertension

A

160/100

ABPM= 150/95

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6
Q

what is stage 3/ severe hypertension

A

clinic =180 syt or 110 diastolic

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7
Q

what people are not included in the definition of primary hypertension

A
diabetics
2ary hypertension
acute hypertension
pregnant people
children and young people
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8
Q

who should be offered ABPM

A

140/90

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9
Q

how is ABPM performed

A

at least two measurements per hour during the day, at least 14 measurements

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10
Q

How is HBPM performed

A

two consecutive seated measurements 1 min apart

record twice a day for 4 days
measurement on the first day is discarded and then take the average

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11
Q

who should be offered antihypertensive drug treatment

A

stage 1 hypertension below 80

stage 2 hypertension at any age

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12
Q

how should people under 40 with stage 1 hypertension be managed

A

investigate 2ary causes of hypertension

assess for target organ damage

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13
Q

what target blood pressure should be aimed for

A

140/90 in people aged below 80, else 150/90

ABPM should be 5 lower

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14
Q

in what cases should antihypertensive drugs be offered

A

stage 2 hypertension
or organ damage present
or 10 year cardiovascular risk >20%

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15
Q

what drugs should be offered to those under 55 who are not African/ caribbean

A

ACE or ARB

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16
Q

what should be offered to those over 55 or of African/ Caribbean descent

A

Calcium blocker

17
Q

what should be offered as a second antihypertensive

18
Q

what should be offered as a third antihypertensive

A

A, C, AND thiazide diuretic

19
Q

what should be offered as a 4th antihypertensive

A

further diuretic, alpha or beta blocker

seek expert advice

20
Q

what lifestyle interventions should be offered

A
diet and exercise
sodium and caffeine
alcohol 
smoking
patient organisations
pros and cons of medications
ANNUAL CARE REVIEW
21
Q

what part of the brain measures osmolality

A

hypothalamus

22
Q

what parts of the vascular system detect low stretch

A

atria and pulmonary vessels

23
Q

what parts of the vascular system detect high stretch

A

aortic arch, carotid sinus and juxtaglomerular apparatus

24
Q

how does the medulla oblongata regulate BP

A

varies ADH from pituitary

plus sympathetic activity

25
what part of the nephron monitors stretch
granular cells of the afferent arteriole
26
what does renin do
converts angiotensinogen to angiotensin 1
27
what enzyme converts angiotensin 1 to 2
angiotensin converting enzyme
28
how does angiotensin 2 raise BP
vasoconstriction stimulating aldosterone production from the renal cortex stimulating the thirst centre stimulating ADH release
29
what is a common side effect of ACE
dry cough | hyperkalaemia
30
what are the side effects of thiazide diuretics
``` hypokalaemia hyperuricaemia hyperglycaemia hypercalcaemia ED thrombocytopaenia ```
31
what type of calcium channel blockers are used in hypertension
dihydropyridine derivatives
32
what are the side effects of calcium blockers
headache and flushing tachycardia ankle swelling gum hypertrophy
33
how do beta blockers work
antagonise sympathetic system and catacholamines at beta one receptors in heart and kidney and beta 2 in lungs
34
what are the side effects of beta blockers
``` bronchospasm bradycardia peripheral vasoconstriciton reduced cardiac output hyperglycaemia ```
35
where are granular cells found
afferent arteriole (stretch)
36
what do macula densa cells detect
sodium
37
what stimulates release of atrial naturetic peptide
high blood volume | reduces water and sodium loads and reduces blood pressure