absorption and secretion Flashcards
describe the process of active transport through the tubular epithelia
The sodium-potassium pump transports sodium from the
interior of the cell across the basolateral membrane crea8ng
a low intracellular sodium concentra8on and nega8ve
intracellular electrical poten8al.
• This causes sodium to diffuse from the tubular lumen into
the epithelial cells through the brush border.
what is an example of secondary active transport
SGLT- sodium glucose co transporter
what substances are reabsorbed in the loop of henle
20% water
25% Na, Cl, and K
what are the features of the thick ascending loop
actively transports sodium, Cl and K and other ions
where do loop diuretics act
thick ascending limb
name some loop diuretics
furosemide
butenamide
what do principle cells in the dct absorb
water and sodium
secretes potassium
what do intercalated cells absorb
pottasium and secrete H+ ions into lumen
synthesises bicarb
where do thiazide diuretics act
sodium, chloride co transporter in the Dct
where do loop diuretics act
thick ascending limb- sodium, chlorine and potassium co transporter
what is spironolactone and eplenenone
aldosterone antagonists
what is amiloride
sodium channel blocker
what can collecting duct excrete
hydrogen ions which help control the acid base balance
what does aldosterone and angiotensin 2 do
increase salt and water reabsorption and increase potassium secretion
what does atrial naturetic hormone do
decrease salt reabsorption
what does parathyroid hormone do
decrease phosphate reabsorption,
increase calcium reabsorption
where is aldosterone produced
adrenal cortex
where does aldosterone act
collecting duct
how does aldosterone work
stimulates the sodium potassium atp-ase pump
what does angiotensin 2 do
contricts arterioles in the kidney
stimulates sodium reabsorption
what receptors does ADH bind to
V2
where does parathyroid hormone act
DCT
what does atrial naturetic peptide do
opposite of aldosterone
decreases blood pressure by increase naturesis and diuresis
what is the function of the DCT
reabsorbs sodium, water and bicarbonate
secretes potassium
synthesises bicarb
