HUMAN GUT FINAL DECK Flashcards
Lederberg, 2001?
Human gut microbiome =, genomes, indigenous microbiota, gut
Zhu, 2010?
Via, human microbiome project, 1000 bacterial species, firmicutes, bacteriodites, shared core
Low resolution surveys to NGS sequencing + advanced bioinformatics
Hay, 1992?
IBD + Chrons = $1.8-$2.6 billion
Wolf, 1994?
Obesity, association, $68.8 billion
Morgan, 2012?
Chrons, GI tract, immune disorder
Genome studies, found churns, affects loci, innate + adaptive response, affected commensal bacteria
Facaelibacterium reduced, metabolize, polysaccharides, N-acetyl glucosamine, anti-inflammatory
Borody, 2012?
Paratuberculosis = chrons
Reversal achieved, anti paratuberculosis, proves involvement + potential
Khan, 2016?
Obesity, dietary, lifestyle, host genetics, doesn’t explain worldwide, excess energy in obese, therapeutic manipulation, energy storage
If escape gut digestion, colon digestion, microbiota, produce short chain fatty acids, correlate fat accumulation
SCFA fecal, obesity associated
Zhang, 2015?
Metaformin, berberine, diabetes treatment, modulate, microbiota, rats, SCFA bacteria increase, disagree