HUMAN GUT FINAL DECK Flashcards

1
Q

Lederberg, 2001?

A

Human gut microbiome =, genomes, indigenous microbiota, gut

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2
Q

Zhu, 2010?

A

Via, human microbiome project, 1000 bacterial species, firmicutes, bacteriodites, shared core

Low resolution surveys to NGS sequencing + advanced bioinformatics

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3
Q

Hay, 1992?

A

IBD + Chrons = $1.8-$2.6 billion

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4
Q

Wolf, 1994?

A

Obesity, association, $68.8 billion

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5
Q

Morgan, 2012?

A

Chrons, GI tract, immune disorder

Genome studies, found churns, affects loci, innate + adaptive response, affected commensal bacteria

Facaelibacterium reduced, metabolize, polysaccharides, N-acetyl glucosamine, anti-inflammatory

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6
Q

Borody, 2012?

A

Paratuberculosis = chrons

Reversal achieved, anti paratuberculosis, proves involvement + potential

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7
Q

Khan, 2016?

A

Obesity, dietary, lifestyle, host genetics, doesn’t explain worldwide, excess energy in obese, therapeutic manipulation, energy storage

If escape gut digestion, colon digestion, microbiota, produce short chain fatty acids, correlate fat accumulation

SCFA fecal, obesity associated

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8
Q

Zhang, 2015?

A

Metaformin, berberine, diabetes treatment, modulate, microbiota, rats, SCFA bacteria increase, disagree

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