Final Exercise physiology deck Flashcards

1
Q

Which equation below accurately represents the CO2 buffering equation at the lungs?

A

HCO3- + H+ = H2CO3 = CO2 + H20

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2
Q

What term is used to describe the blueish tinge tissue exhibits during hypoxia?

A

Cyanosis

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3
Q

Which of the following occur immediately when exposed to high altitude?

A

The ventilation rate increases

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4
Q

What distance above sea-level would be classed as ‘high’ altitude, where altitude sickness and acclimatisation become clinically relevant, and performance is considerably impaired?

A

3000 – 6000 meters

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5
Q

What is the average lactate concentration at rest?

A

1 mM

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6
Q

Which are the physical activity guidelines for children and adolescents?

A

A. 60 or more minutes of MVPA/day

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7
Q

The QRS complex represents

A

Ventricular depolarization

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8
Q

Where is the electrical activity of the heart generated?

A

Sinoatrial node

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9
Q

How does the process of aging affect VO2max in adult men and women?

A

It declines approximately 1% per year and occurs twice as fast in sedentary compared to physically active

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10
Q

Men and women attain their highest bone mass levels between the ages…?

A

20-40

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11
Q

What percentage of our vitamin D comes from the sun?

A

90%

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12
Q

What is the amino acid precursor to dopamine?

A

Tyrosine

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13
Q

List some of the key physiological changes that occur with age?

A

40% decline in spinal cord axons

10% decline in nerve conduction velocity, due to structural changes in myelinated neurones, resulting in increased internal distances, decreasing signal jumping over Schwann cells

Also a loss of fastest conducting axons and decrease in soma size

It declines approximately 1% per year and occurs twice as fast in sedentary compared to physically active (VO2)

Bone mass decreases after 40

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14
Q

Explain the topic of altitude sickness?

A
Acute altitude sickness
‣ Headache 
‣ Nausea
‣ Fatigue
‣ Causes Ascending faster than 500m/d

high altitude pulmonary oedema:
develops 2-3 days when higher than 2500m

Can be fatal within hours

Accumulation of fluid in the lungs that prevents air spaces from opening up and filling with fresh air with each breath

bad coughing symptoms

high altitude cerebral oedema:
An increase in blood flow to the brain is a normal response to low oxygen levels, as needs to maintain the oxygen to the brain. However, if the blood vessels in the brain are damage fluid may leak out and result in death

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15
Q

What’s the ventilatory threshold?

A

The point at which pulmonary ventilation increases disproportionately with oxygen consumption during graded exercise

Figure
VO2 on the x axis (VO2 ml.min^-1) up to 4500
VCO2 on the y axis (ml.min^-1) up to 6000

Draw one line with not that steep gradient

Draw one with a steeper gradient further on and crossing over

Label crossing over point as ventilatory threshold

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16
Q

Calculations for Oxygen carrying capacity of blood?

A

Units are ml per litre of blood

{O2} = ({HB} x 1.34 x 0.97) + (PO2 x 0.003)

{HB} = males 150g/1L, females 130g/1L

PO2 = 100

  1. 34 represents ml O2 g Hb
  2. 97 represents 97% saturation
  3. 003 represents O2 solubility

If asked:
Total = both sides of the equation

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17
Q

Toddler activity guideline?

A

Physically active daily for at least 180 minutes (3hours), spread throughout the day.
‣ All under 5s should minimise the amount of time spent being sedentary (being restrained or sitting) for extended periods.


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18
Q

Equation for CO2 + H2O to HCO3- and it relating to chloride shift?

A

takes place when the blood gives up oxygen and receives carbon dioxide.

CO2 + H2O = (via carbonic anhydrase) H2CO3 = H(+) + HCO3-

HCO3- leaves the red blood cell, Cl- moves in to restore charge

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19
Q

Ficks law of diffusion?

A

THE RATE OF GAS TRANSFER IS PROPORTIONAL TO THE TISSUE AREA, THE DIFFUSION COEFFICIENT OF THE GAS, AND THE DIFFERENCE IN PARTIAL PRESSURE OF THE GAS ON THE TWO SIDES OF THE TISSUE, AND INVERSELY PROPORTIONAL TO THE THICKNESS

V GAS = ((P1-P2) x A x D)) / T

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20
Q

What is Boyle’s Law?

A

Pressure of a gas in a closed container inversely proportional to volume of container at a constant temperature

P1V1 = P2V2

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21
Q

What is Henry’s law?

A

When a mixture of gas is in contact with a liquid each gas dissolves in the liquid in proportion to it’s partial pressure and solubility until equilibrium is achieved and the gas partial pressure are equal in both locations

Solubility is constant

Pressure gradient is critical - gas diffuse from high pressure areas to low pressure areas

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22
Q

What is Daltons law

A

Dalton’s law of partial pressures states that the total pressure of a mixture of gases is the sum of the partial pressures of its components: P Total = P gas 1 + P gas 2 + P gas 3 .

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23
Q
  1. Describe the changes in neural function with training and age?
A

40% decline in spinal cord axons

10% decline in nerve conduction velocity, due to structural changes in myelinated neurones, resulting in increased internal distances, decreasing signal jumping over Schwann cells

Also a loss of fastest conducting axons and decrease in soma size

Resistance training can reduce it by increasing muscle hypertrophy

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24
Q

What is voluntary activation and the formula?

A

The level of neural drive to muscle during exercise

estimated by interpolation of a single supramaximal electrical stimulus to the motor nerve during an isometric voluntary contraction

(%) = (1 –a/b) × 100

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25
Q

Human breathing?

A

Accessory muscles
Diaphragm 75% (in the exam)
Intercostal muscles
Abdominal muscles

Steps of Inhalation:
Diaphragm flattens

External intercostals Up and Out, causing elevation of ribs

Increase Volume

Decrease Pressure

Air rushes in

Steps of exhalation at rest:
Passive process

Elastic recoil

Decrease Volume

Increase pressure

Air forced out

During exercise:
Becomes an active process

Muscles used are the internal intercostals, external obliques, rectus abdomens, transverse abdominus

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26
Q

Acute and prolonged affects of altitude?

A

Immediate response to increased altitude:
Hyperventillation
Increase in blood flow
Resting system blood pressure increases
Increase in sub maximal blood flow compensates for arterial
EPO concentrations rapidly increase, then goes back to normal

Longer term response to increased altitude:
Increased blood O2 carrying capacity:

Initial decrease in plasma volume

So increase in RBC concentration and Hb synthesis

27
Q

Wilkerson et al (2017) notes for exam?

A

8 well trained male cyclists completed 2 50 mile TT

One after consuming nitrate rich beetroot juice, and one after consuming a placebo

BR elevated plasma Nitrate and reduced completion time by 0.8% which wasn’t statistically significant

Problems:
trying to answer does Nitrate supplementation work in longer races as well as does it work in better trained athletes

In pre lab they only did a 10 mile TT for familiarisation which isn’t the same as the 50 Mile tested,

Good things:
0.8% valid in competition

identify responders and non responders to the beetroot juice

Further study:
Use an optimal nitrate loading regimen
Further supplementation eg during
At least one proper familiarisation trial conductied
Ecological validity would be improved by completing the TT on the road, even though this is conflicted by weather

28
Q

What is tidal volume?

A

Amount per breath

29
Q

Breathing frequency?

A

Number of breaths

30
Q

How to work out alveolar ventilation?

A

0.7 x tidal volume

31
Q

How to work out dead space ventilation?

A

0.3 x tidal volume

32
Q

What is inspiratory reserve volume?

A

Maximum volume of air that can be inhaled (from top of tidal volume on graph)

33
Q

What is Expiratory reserve capacity?

A

Maximum volume of air that can be voluntarily exhaled (from bottom of tidal volume on graph)

34
Q

What is residual volume?

A

Volume of air remaining in the lungs after maximal exhalation

35
Q

What is vital capacity?

A

Maximum volume that can be inhaled and exhaled (IRV + Tidal volume + ERV)

36
Q

What is FRC functional residual capacity?

A

Volume of air present in the lungs at the end of passive expiration (ERV + RV)

37
Q

What is the respiratory muscle metaboreflex?

A

Fatiguing contractions of the diaphragm expiratory and and accessory respiratory muscles

Increase in reflex activating metabolites
Increase in group III/IV phrenic afferent (up to the brain) discharge

Brain says:

sympathetic efferent discharge, limb vasoconstriction and locomotor muscle fatigue

And decrease O2 transport to the limbs of the working muscles

38
Q

Question on T and Z scores on bone mass?

A

-1 to -2.5 = low bone mass
smaller than - 2.5 = osteoporosis

T looks at the small group

Z looks at the whole population

T scores used for bone density

(X - Xbar) / standard deviation

DXA or QUS

Health of the bone is assed by biochemical markers, calciotrophic hormones and it’s rate of collagen synthesis

39
Q

How to draw the flow volume question?

A

y axis is flow goes positive and negative, y axis is labelled flow, positive is +ve = expiration, negative is -ve = inspiration

Volume is on the x axis, make sure at the end there is space for the residual volume (0-2), then go up to 6

Triangle with semi circle on bottom, it reaches the y axis

Obstructive lung condition = right side of the triangle slopes down

Restrictive is the same but smaller

Exercise induced asthma the same but keeps getting smaller over time (smaller triangles)

40
Q

Total lung capacity =?

A

ERV + Tidal Volume + IRV + residual volume

41
Q

Inspiratory capacity = ?

A

IRV + Tidal volume

42
Q

Minute ventilation?

A

Breathing rate x tidal volume

43
Q

Lactate threshold and turning point on a graph?

A

lactate threshold - The first increase above baseline

Lactate turn point - When there is a sudden increase in Lactate

Draw on graph:
x axis pace 0mph to 15 mph

Lactate on y 0mmol to 10 mmol

Small increase around 8 mph mark with little pointers, then a large exponential increase at 10 mph = lactate turning point

44
Q

What is VO2?

A

The difference between volume of gas inhaled and volume of gas exhaled per unit of time

VO2 = {(VI x Fio2) - (Ve x Feo2)} / T

The gold standard aerobic fitness test, used extensively in the assessment of athletes and research.

Underpinned by Fick equation

the maximum or optimum rate at which the heart, lungs, and muscles can effectively use oxygen during exercise, used as a way of measuring a person’s individual aerobic capacity at sea level

Measured by an exercise graded test

Achievement of ‘plateau’ of oxygen consumption

RPE > 17

45
Q

What’s in the alveoli?

A

Type 1 cell: More numerous, enable gas exchange

Type 11 cell: Produce surfactant prevents lungs collapsing

46
Q

Whats are the respiratory control centres in the brain?

A

Pons:
Apneustic area
Pneumotaxic area

Medulla Rhythmicity area:
Ventral and Dorsal group

47
Q

More features of the pons?

A

Apneustic area:
Prolonged and slow rate of breathing
Overridden by pneumotaxic

48
Q

Features of the pneumotaxic area?

A

Inhibitory impulse, limits duration of breath in

Breathing becomes faster by limiting breathing in

49
Q

More features of the medulla oblongata?

A

Rhythmicity area:
Controls basic rate of breathing
Dorsal respiratory group - mainly inspiratory , can also talk to the ventral, but ventral can’t talk back
Ventral respiratory group

50
Q

Features of the peripheral chemoreceptors?

A

Due to Glomus cells, which have K+ going in and out of them

If oxygen is down 60mmHg, the potassium channels close, so potassium builds up in the cell, calcium channels open due to increased voltage so calcium rushes in

Exocytosis of vesicles from cell which are filled with dopamine, which increases breathing rate

51
Q

Cardiac conduction sequence?

A

Sinoatrial node

Current makes right atrium contract

Current goes to Bachmann’s bundle makes left atrium contract

Through septum of heart

Goes to atrioventricular node

His bundle

Purkinje fibers

Left posterior bundle and right bundle, ventricles contract

52
Q

ECG wave?

A

P wave small hump - atrial depolarisation

QRS complex - down, large up, down, normal = ventricular depolarisation

T wave - small hump - ventricular repolarisation

QRS hides P wave repolarisation§

53
Q

What is the FICK EQUATION?

A

Underpins VO2

VO2 (ml/O2/min) = Q (l.min^-1) x (CaO2 - CvO2)

54
Q

Why is there increased extraction of O2 from the blood during exercise?

A

Sigmoid curve

Acidity, Pco2, 2,3-BPG, and temperature help remove oxygen

Acidosis increases during exercise, pH decreases, affinity of Hb decreases, more O2 delivered to acidic sites

Pco2 rises, affinity of Hb decrease, more oxygen delivered

BPG formed during glycolysis helps to unload by binding with Hb

Temperature increases affinity of Hb decreases, more O2 is delivered to warmed up muscle

55
Q

Types of Axoplasmic transport?

A

They are moved along Microtubules (made of tubulin)

Anterograde transport the movement of molecules/organelles outward, from the cell body, due to Kinesin

Retrorade transport (toward the cell body) due to Dynein

56
Q

What are Cholinergic neutrons?

A

Release Acetylcholine (ACh)

57
Q

Equation for BMI?

A

Weight(kg) / Height^2 (m)

58
Q

Physical activity guideline for adults?

A

2.5 hours a week

muscle work 2 times a week

59
Q

Calculations for cardiac output?

A

Total volume of blood pumped by the ventricle per minute

Q (L.min^-1) = HR x SV
SV(ml) = EDV - ESV

so Q (L.min^-1) = HR x (EDV - ESV)

60
Q

Calculations for blood pressure?

A

Mean arterial blood pressure = 2/3 DBP + 1/3 SBP

units are mmHg

61
Q

Equation for find change of blood in arterial and Venus?

A

CaO2 - CvO2 = difference

Do arterial - however much oxygen is used

Units are ml of O2

62
Q

Equation for running economy?

A

If not given VO2

VO2 (ml/Kg/Min) = 13.5(Speed (m\s)) - 8.5

If given speed in km/hr, /60 then /60 then x 1000

But if given Vo2 in ml/kg/min

O2 cost (ml/kg/km) = VO2 (ml/kg/min) / Speed (Km/hr) /60)

This is on the exam

63
Q

Describe action potential?

A

-70mmv

Generated by SOPI pumps

Depolarisation occurs due to a stimulus

If hits -55mv, action potential generated, pushing us to + 30 mmv, as sodium channels open

Repolarisation, sodium channels close, potassium channels open goes down,

takes too long causing hyper-polarisation

64
Q

Typical ECG response to exercise?

A

Minor changes in P wave form

Superimposistion of P and T waves of successive beats (starts to look like an “M”
Slight decrease in R wave amplitude
Q wave may be deeper
Increase in T wave amplitude
Minimal shortening of QRS complex
Depression of J point (the J point is found where the S wave makes its sharp deviation (right hand turn) toward the T wave
At rest the J point should come back to the isoelectric line
Rate related shortening of QT interval

Will be in exam