FINAL ANTIMICROBIAL DECK

Question 1

Review on antimicrobial resistance, 2014?

Answer 1

New approaches, 10 million 2050

Question 2

Nue, 1992?

Answer 2

Decades antibiotics overuse

Gentic material, Chromosomal adaptation, R plasmid

Anti virulence, low selection pressure

Question 3

Davies, 2010?

Answer 3

Understanding, global solution x 2

Antibiotics overuse, mechanisms form, combat

Question 4

Dennis, 2014?

Answer 4

Manipulates, immune, conc grad, mineral desire

Chelating complex, ferric iron, cedifercol

Pseudomonas aeruginosa, bacterium, nosomical, multi-drug, resistant, uptake, transporter

Question 5

Dreschel, 1997?

Answer 5

Siderophores, forage, minerals-iron, depleted, immune response

Question 6

Mollman, 2009?

Answer 6

Trojan horse, antibacterial traits, cell death

Question 7

Portsmouth, 2018?

Answer 7

Effective, Pseudomonas aeruginosa, 73%, 252, urinary tract

Question 8

Poole, 2011?

Answer 8

Resistance, Pseudomonas aeruginosa, chemotherapy

Resistance, multifactorial, chromosomal mutations, horizontal gene transfer

Multi-drug efflux, membrane permeability, targets

Question 9

Chen, 2004?

Answer 9

Transformation = , transfer of DNA, extracellular milieu, into cytoplasm

DNA translocate complex, at cytoplasmic membrane, helps

Genetic transformation, spreads resistance

Question 10

Ge, 2012?

Answer 10

SDHA gene, codes 1 subunit, succinate dehydrogenase, enzyme

Legionella pnuemophila, DNA, into macrophage cytosol, exaggerated, by absence, SDHA