ANTI VIRUELNCE FINAL DECK Flashcards
Johnson, 1991?
Virulence factors = ,Properties, products, structures, overcome, host defences, colonise or invade
Lenski, 1998?
Economic cost of antibiotics
Miller, 2001?
Quorum sensing, control, gene expression, fluctuations, cell population density, cause disease
Rasko, 2010?
Regulated, AHL’s, gene expression, virulence factors, biofilm formation
Interferring agents, agonis, inhibitors, AHL’s, Enzymes or antibodies
Prevent signal, prevent disease
Dong, 2005?
Quorum quenching, AHL degradtion enzymes, from bacteria, disable AHL
Lin, 2003?
Ralstonia SP, bacterium, gene cloned, for AHL deactivation, effective, in Escherichia Coli
Simoes, 2010?
Biofilms, extracellular, matrix, community, free swimming to surface attached, resistant phenotype, difficult to eradicate, foodbourne pathogen
Transport, planktonic cells, liquid to surface, adsorption of cells at surface, cell-cell signalling molecules produced, transport within biofilm
Substrate metabolism, cell growth, replication, EPS production
Lee, 2014?
Staphylococcus aureus, human pathogen, a toxin, haemolytic
Biofilm, aids virulence
Cis nerolidol, oil, plants, flowers, inhibited formation, then, haemolytic activity, then a-toxin gene hla
Hence anti virulent