Hormones Flashcards
List the hypothalamic hormones
List the pituitary hormones
Describe the function of TRH
thyrotropin-releasing hormone released from the hypothalamus & stimulates the release of thyroid hormones & prolactin
Describe the function of GnRH
gonadotropin-releasing hormone released from the hypothalamus & stimulates the release of LH & FSH
Describe the function of CRH
corticotropin-releasing hormone released from the hypothalamus & stimulates release of ACTH (targeting cortisol)
Describe the function of GHRH
growth hormone releasing hormone released from the hypothalamus & stimulates release of GH (targetting IGF-1)
Describe the function of somatostatin
released from the hypothalamus & inhibits the release of GH & TSH
Describe the function of dopamine on hormones
inhibits release of PRL
Describe the function of oxytocin
stimulates uterine contraction/milk ejection
produced in hypothalamus, released from posterior pituitary
Describe the function of prolactin inhibiting hormone
Secreted by the hypothalamus, inhibits synthesis & secretion of prolactin
Describe the function of ACTH
adrenocorticotropic hormone secreted by the anterior pituitary, stimulates cortisol release & regulates aldosterone
Describe the function of ADH
antidiuretic hormone/vasopressin produced in the hypothalamus, regulates water balance
Stored & released by the posterior pituitary
Describe the function of TSH
thyroid stimulating hormone secreted by the anterior pituitary, stimulates thyroid hormone release
Describe the function of LH
luteinizing hormone secreted by the anterior pituitary, stimulates ovulation/testosterone production
Describe the function of FSH
follicle stimulating hormone secreted by the anterior pituitary, stimulates follicle/sperm development
Describe the function of GH
growth hormone secreted by the anterior pituitary, stimulates growth & cell reproduction
- mediated by insulin like growth factors
Describe the function of PRL
prolactin secreted by the anterior pituitary to stimulate milk production/lactation
Describe the function of MSH
melanocyte stimulating hormone secreted from the pars intermedia of the pituitary, regulates pigmentation
List the thyroid & parathyroid hormones
Thyroid: T3, T4
Parathyroid: PTH, calcitonin
Describe the function of T3
Triiodothyronine secreted by the thyroid, regulates metabolism & growth
Describe the function of T4
thyroxine secreted by the thyroid, precursor to T3, regulates metabolism
Describe the function of PTH
parathyroid hormone secreted by the parathyroid
- regulates Ca & Phos levels in the blood
- stimulates calcitriol conversion from cholecalciferol in the proximal convoluted tubule
- aids Ca absorption in the distal convoluted tubule
- aids osteoclast activity
Describe the function of calcitonin
secreted by the parathyroid
- regulates Ca levels in the blood by inhibiting bone breakdown
- decreases serum phos by moving it into the bone
- used to treat severe hypercalcemia
List the pancreatic hormones
Describe the function of INS
insulin secreted by the beta cells of pancreatic islets
- regulates glucose uptake & storage
Describe the function of glucagon
secreted by alpha cells of pancreatic islets
- increases blood glucose levels
Describe the function of SST
somatostatin secreted by delta cells of pancreatic islets
- inhibits insulin & glucagon release
Describe function of PP
pancreatic polypeptide secreted by PP cells in pancreatic islets
- regulates pancreatic functions & stimulates secretion of GIT enzymes
List the gonadal hormones
- testosterone
- estrogen
- progesterone
List the gastrointestinal hormones
- gastrin
- cholecystokinin (CCK)
- Secretin
- ghrelin
- leptin
List the kidney hormones
- renin
- erythropoietin
- calcitriol
- epinephrine
- norepinephrine
- gonadal hormones
Describe the function of calcitriol (Vit D)
secreted by kidneys
- active form of Vit D from diet & UV
- converted by PTH in PCT from cholecalciferol
- helps absorb Ca & Phos in GIT
- aids in mineralization of bones
What is the most potent mineralcorticoid in our body
aldosterone (regulates lytes in ECF)
- regulated by RAAS, plasma K concentration, ACTH, increased Na
Define paracrine hormones
secreted by cells into ECF & affect neighboring cells
- hypothalamus hormones acting on pituitary gland
Define autocrine hormones
secreted by cells into ECF & affect same cell
- prostaglandin, insulin, leptin
Define endocrine hormones
released by glands/specialized cells into blood & act on cells at another location
Which hormones are proteins & polypeptides
- Hypothalamus hormones
- 3 Ps: pituitary, pancreas, parathyroid hormones
Which hormones are amino acid tyrosine based hormones
- thyroid hormones
- adrenal medulla hormones
Which hormones are steroids
- gonadal, adrenal cortex, placental hormones
Which hormones are water soluble
peptides & catecholamines
- ex. DA, epi, norepi
- ex. pituitary hormones
Which hormones are lipid-soluble
steroids & thyroid hormones
What is the most significant glucocorticoid in our body
cortisol
- released in response to ACTH, eating, activity, stress
- promotes mobilization of energy stores
- promotes glycogenolysis on glucagon
- promotes vasoconstriction & bronchodilation on catecholamines