Heme Malignancies

Question 1

Lymph nodes that are soft, tender, mobile but enlarged suggest…

Answer 1

inflammation/infection

Question 2

Lymph nodes that are firm, rubbery, mobile and enlarged suggest…

Answer 2

lymphoma

Question 3

Lymph nodes that are hard, fixed, non-tender suggest…

Answer 3

carcinoma

Question 4

At what stage of hematopoiesis does lymphoma affect/occur

Answer 4

mature lymphocytes (B cells and mature T cells)

Question 5

Describe leukemia

Answer 5

cancer of blood & bone marrow characterized by uncontrolled accumulation of malignant WBC

Question 6

Describe the etiology of acute versus chronic leukemia

Answer 6

also myeloid vs lymphoid

Question 7

Describe the difference in clinical presentation between acute and chronic leukemia

Answer 7

Question 8

Describe the diagnosis of leukemia

Answer 8

Question 9

Describe the risk factors for the different forms of leukemia (acute v chronic & myeloid v lymphoid)

Answer 9

Question 10

Describe the etiology of acute myeloid leukemia and the common emergencies within

Answer 10

Question 11

Describe the presentation of acute myeloid leukemia

Answer 11

Question 12

Describe the presentation of tissue infiltration in AML

Answer 12

Question 13

Describe the presentation of leukostasis in AML

Answer 13

Question 14

Describe the presentation of disseminated intravascular coagulation in AML

Answer 14

Question 15

Describe the presentation of tumor lysis syndrome in AML

Answer 15

Question 16

Describe the treatment of AML

Answer 16

Question 17

Describe the treatment for leukostasis in AML

Answer 17

leukapheresis & emergent initiation of chemo

Question 18

Describe the treatment for DIC in AML

Answer 18

replace clotting factors and platelets & start chemo

Question 19

Describe the treatment of tumor lysis syndrome in AML

Answer 19

hydrate, allopurinol to clear uric acid, dialysis as needed

Question 20

Describe the etiology of acute lymphoblastic leukemia

Answer 20

Question 21

Describe the presentation of ALL

Answer 21

Question 22

Describe the treatment for ALL

Answer 22

Question 23

Describe the etiology of chronic myeloid leukemia

Answer 23

Question 24

Describe the presentation of CML

Answer 24

Question 25

Describe the treatment for CML

Answer 25

Question 26

Describe the etiology of chronic lymphoid leukemia

Answer 26

Question 27

Describe the presentation of CLL

Answer 27

Question 28

Describe the treatment for CLL

Answer 28

Question 29

Describe the etiology of lymphoma (Hodgkin & Non-Hodgkin)

Answer 29

Question 30

Describe the presentation of lymphoma

Answer 30

Question 31

Describe the diagnostics for lymphoma

Answer 31

Question 32

Describe the staging of lymphoma

Answer 32

Question 33

Describe the etiology of myeloma

Answer 33

Question 34

Describe the etiology of monoclonal gammopathy of uncertain significance (MGUS)

Answer 34

Question 35

Describe the etiology of multiple myeloma

Answer 35

Question 36

Describe the presentation of multiple myeloma

Answer 36

Question 37

Describe the diagnosis of myeloma

Answer 37

Question 38

Describe the treatment for myeloma

Answer 38

Question 39

Describe the etiology of myelodysplastic syndromes (MDS)

Answer 39

Question 40

Describe the presentation of MDS

Answer 40

Question 41

Describe the diagnosis of MDS

Answer 41

Question 42

Describe the treatment of MDS

Answer 42

Question 43

Describe the etiology of myeloproliferative neoplasms

Answer 43

Question 44

Describe the presentation & complications of MPN

Answer 44

Question 45

Describe the diagnosis of MPN

Answer 45

Question 46

Describe the treatment of MPN

Answer 46

Question 47

Describe the etiology of aplastic anemia

Answer 47

Question 48

Describe the presentation & diagnosis of aplastic anemia

Answer 48

Question 49

Describe the treatment of aplastic anemia

Answer 49

Question 50

What are some complications of aplastic anemia

Answer 50

development of myelodysplastic syndromes or acute myeloid leukemia