HOOFDSTUK 30 Flashcards

CALCIUM HOMEOSTASE

1
Q

functies van Calcium

A
  • secretie kliercellen
    spiercontractie
    enzymactiviteit
    cofactor voor bloedstolling
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2
Q

Ca in plasma

A

8 - 10 mg/dL

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3
Q

verhogen van Ca

A

dunne darm reabsorptie
botafbraak
reabsorptie thv nier

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4
Q

dalen van [Ca]

A

secretie van Ca naar darm
botvorming dmv osteoblasten
filtratie van Ca naar nier

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5
Q

PTH

A

parathyroidhormoon
= calciumverhogend hormoon
-> stimuleert botafbraak

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6
Q

activiteitsplaatsen van PTH

A

geactiveerd PTH stimuleert botafbraak
stimulatie reabsorptie van Ca uit de nier
reabsorptie uit darm via activering vitamine D

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7
Q

waar zitten de calciumsensoren

A

thv bijschildklier

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8
Q

calcitriol?

A

Ca-stijging

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9
Q

calcitonine

A

osteoblasten stimuleren
osteoclasten inhiberen
= betere botkwaliteit

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10
Q

vitamine D (maken?)

A

7-dehydroxycholesterol -> UV = vitamine D3

Vitamine D3 -> hydroxylatie lever = 25-OH-vit D3

25-OH-vit D3 -> hydroxylatie nier = 1,25-OH2-vit D3

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