Hematology - TopHat Flashcards
An absolute reticulocyte count above ___ is consistent with regenerative anemia in a dog.
a. 200,000
b. 8,000
c, 20,000
d. 80,000
d. 80,000
An absolute reticulocyte count above ____ is consistent with a regenerative anemia in a cat.
a. 500
b. 2,000
c. 80,000
d. 50,000
d. 50,000
How would you characterize this patients anemia?
a. Microcytic, hypochromic, and nonregenerative
b. Macrocytic, hypochromic, and regenerative
c. Microcytic, hypochromic, and regenerative
d. Normocytic, normochromic, and nonregenerative
c. Microcytic, hypochromic, and regenerative
What type of anemia do you think Kira has and what do you suspect its cause is?
a. Nonregenerative anemia due to her unregulated diabetes
b. Regenerative anemia due to hemolysis
c. Nonregerative anemia due to underlying cancer
d. Regenerative anemia due to blood loss
d. Regenerative anemia due to blood loss
Which of the following clinicopathologic findings would support your suspicion that your patient has IMHA?
a. Microcytosis, hypoproteinemia, and thrombocytosis
b. Hyperbilirubinemia, hypophosphatemia, and hyperglycemia
c. This is a silly question. There is one definitive diagnostic test for IMHA: Coomb’s test
d. Hyperbilirubinemia, autoagglutination, and spherocytes
e. Leujopenia, hemoglobinemia, and a negative Commb’s test
d. Hyperbilirubinemia, autoagglutination, and spherocytosis
Which of the following should be ruled out before making a diagnosis of primary IMHA (may be multiple answers)?
a. Non-immune hemolysis due to zinc toxicity
b. Secondary immune hemolysis due to Babesia infection
c. Non-immune hemolysis due to hyperkalemia
d. Secondary immune hemolysis due to lymphoma
a, b, and d
What is the frontline immunosuppressive therapy in IMHA?
a. aspirin
b. Glucocorticoids
c. Azathioprine
d. Heparin
e. Cyclosporine
b. Glucocorticoids
What is the most common reason for sudden death in IMHA?
a. Secondary infection
b. Thrombosis
c. Arrhythmia
d. Blood loss
b. thrombosis
Duke is a 9 year old MC 40kg mixed breed dog. He has a HCT of 19% and spherocytes on his CBC. He is icteric, lethargic, tachypneic, and tachycardic. His PT and aPTT are within normal limits. What blood product do you want to give Duke?
a. Stored whole blood
b. Fresh frozen plasma
c. Frozen plasma
d. Packed red blood cells
e. No transfusion
d. Packed red blood cells
Malaika is a 10 yearold FS DLH. Her HCT is 18% and she has stage 3 CKD. Her RR is 20 when not purring, HR is 150, and BP is 130 mmHg. Her temperature is 100 degrees F. What blood product do you want to give Malaika?
a. stored whole blood
b. fresh frozen plasma
c. frozen plasma
d. packed red blood cells
e. no transfusion
e. no transfusion
Sarge is a 1 year old MC DSH. His HCT is 12%. He is icteric, vomiting, and lethargic. His HR is 220, RR 50 temperature is 98 degrees F, and his BP is 90 mmHg. You do a blood smear and find evidence of Mycoplasma. What blood product do you want to give Sarge?
a. stored whole blood
b. fresh whole blood
c. fresh frozen plasma
d. packed red blood cells
e. no transfusion
d. Packed red blood cells
Jenny is a 4 year old FS German Shepherd that is presenting with a 1 week history of lethargy, inappetance, and vomiting. She is tachypneic with harsh lung sounds. Her HCT is 42%, platelet estimate is greater than 200,000, PT and aPTT are prolonged. What blood product do you want to give Jenny?
a. stored whole blood
b. fresh frozen plasma
c. packed red blood cells
d. no transfusion
b. Fresh frozen plasma
Which of the following is NOT a player in primary hemostasis?
a. Platelets
b. von Willebrand factor
c. Endothelium
d. Factor IX
d. factor IX
In a severely thrombocytopenic dog, what signs of bleeding might you see?
a. Epistaxis
b. Hemoabdomen
c. Melena
d. Hemoptysis
a, c, and d
What is the most common acquired disorder of primary hemostasis?
a. rodenticide toxicity
b. von Willebrand disease
c. thrombocytopenia
d. liver disease
c. thrombocytopenia
What ITP treatment is available that increases platelet count but would have no use in IMHA?
a. azathioprine
b. mycophenolate
c. vincristine
d. prednisone
c. vincristine
What is the most common hereditary disorder of primary hemostasis?
a. melena
b. abdominal cavity hemorrhage
c. von Willebrand disease
d. macrothrombocytopenia
e. platelet count +/- vWF testing
f. Rodenticide toxicity
g. platelet consumption
c. von Willebrand disease
Which of the follwing is a cause of acquired thrombocytopenia?
a. melena
b. abdominal cavity hemorrhage
c. von Willebrand disease
d. macrothrombocytopenia
e. platelet count +/- vWF testing
f. Rodenticide toxicity
g. platelet consumption
g. platelet consumption
You would conduct a BMBT after the following:
a. melena
b. abdominal cavity hemorrhage
c. von Willebrand disease
d. macrothrombocytopenia
e. platelet count +/- vWF testing
f. Rodenticide toxicity
g. platelet consumption
e. platelet count +/- vWF testing
Which of the following is a sign of a primary hemostatic defect?
a. melena
b. abdominal cavity hemorrhage
c. von Willebrand disease
d. macrothrombocytopenia
e. platelet count +/- vWF testing
f. Rodenticide toxicity
g. platelet consumption
a. melena
What blood products contain viable platelets?
a. stored whole blood
b. platelet rich plasma
c. fresh frozen plasma
d. fresh whole blood
e. platelet concentrate
b. platele rich plasma
d. fresh whole blood
e. platelet concentrate
Brutus is a 9 year old male castrated goldendoodle. He presented for a nose bleed. He has already been worked up for nasal disease and his platelet count and clotting times are normal. What do you want to do next with Brutus?
a. BMBT
b. vWF testing
c. Chemistry panel
d. Hmm… all of the above sound like good ideas
d. Hmm… all of the above sound like good ideas
Who are the key players in primary hemostasis, defects in which would lead to prolonged BMBT?
a. Coagulation factor X, fibroblasts, von Willebrand factor
b. Endothelium/vasculature, platelets, tissue factor
c. fibroblasts, platelets, von Willebrand factor
d. Endothelium/vasculature, platelets, von Willebrand factor
d. Endothelium/vasculature, platelets, von Willebrand factor
Which model of secondary hemostasis better reflects your lab testing like PT and aPTT?
a. Traditional waterfall/cascade model
b. Cell-based model
a. Traditional waterfall/cascade model
Which model better reflects secondary hemostasis as it happens in the dog or cat?
a. Waterfall/cascade model
b. Cell-based model
b. Cell-based model
Which of the following diseases is better explained by the cell-based model than the waterfall model?
a. von Willebrand disease
b. ITP
c. Hemophilia A
d. Fibrinogen deficiency
c. Hemophilia A
Which blood products contain FVIII?
a. fresh whole blood
b. stored whole blood
c. fresh frozen plasma
d. frozen plasma
e. packed red cells
a. Fresh whole blood
c. fresh frozen plasma
What inhibitor of thrombin is decreased during a disease process where albumin is lost/not absorbed? The end result is risk of ______.
a. Protein C, bleeding
b. Protein S, clotting
c. Antithrombin, clotting
d. Tissue factor pathway inhibitor, bleeding
c. antithrombin, clotting
