Hematology #2

Question 1

What is the MC hereditary bleeding disorder?

Answer 1

Von Willebrand Disease

Question 2

What treatment is given for vWF?

Answer 2

Desmopressin (DDAVP)

Question 3

What are some clinical manifestations of Factor V Leiden Mutation?

Answer 3

• Increased incidence of DVT, PE, hepatic vein or cerebral vein thrombosis
• Increased risk of miscarriages during pregnancy

Question 4

What is the pathophysiology of Factor V Leiden Mutation?

Answer 4

-Mutated factor V is resistant to breakdown by activated protein C, leading to increased hypercoagulability

Question 5

What is the treatment for Factor V Leiden Mutation?

Answer 5

Indefinite anticoagulation

Question 6

What is Heparin Induced Thrombocytopenia (HIT)?

Answer 6

Acquired thrombocytopenia within first 5-10 days of initiation of Heparin

Question 7

Management of HIT

Answer 7

• Discontinue all Heparin + initiate non-Heparin anticoagulants
• Start Argatroban + Lepirudin