GI 8: Hepatic, Pancreatic and Intestinal Secretions Flashcards
small intestine secretions come from the ___
crypt of Lieberkuhn
goblet cells secrete ___
mucous
paneth cells secrete ___ and are capable of ___
lysozymes; phagocytosis
enteroendocrine cells secrete the hormones __, ___ or ___
secretin; cholecystokinin ; GIP
secreti is secreted by )__ cells
s
CCK is secreted by ___ cells
I
GIP is secreted by ___ cells
K
the pH of secretions of the small intestine is slightly ___
alkaline
secretions of the small intestine are mostly regulated by local reflexes w/I the ENS initiated by __ or ___ stimuli
irritative or tactile
bile is a substance produced by the __, stored in the __ and secreted in the ___
liver; gallbladder; small intestine
bile contains what 6 components?
- bile salts
- lecithin
- HCO3
- cholesterol
- bilirubin
trace metals
what is the function of bile salts and lecithin?
solublize and emulsify fat
what s the function of bicarbonate?
neutralize stomach acid
what is the function of cholesterol, bilirubin, trace metals?
excreted as waste in faces
what are the 3 main bile functions?
- lipid emulsion
- pH
- waste excretion
jaundice is caused by an excess of __
bilirubin
parasympathetic vagus nerve and ENS stimulation induces ____ by the liver and release of bile from the ___
production; gallbladder
secretin, produced by the ____, triggers the bile ___ in the liver
duodenum; synthesis
CCK produced by the ___ triggers the contraction of the ___ and the relaxation of the ___, resulting in the release of bile
duodenum; gallbladder; sphincter of oddi
95% of bile salts are reabsorbed in the ___ and are returned to the liver, where they will trigger___
ileum; more secretion of bile
t/f both the gallbladder and pancreas use the sphincter of oddi
true
pancreatic secretions have what 2 components?
aqueous and enzyme rich
the aqueous component of pacreatic secretions is produced by the ___ cells and contains HCO3- that neutralize acidic chymeand pepsin while activating pancreatic enzyme
duct
___ cells produce the enzyme rich components of pancreatic secretions
acinar
HCO3 crosses the apical memnbrane by the ___ transporter
Na/HCO3
trypsin and chymotrypsin break down ___
proteins
pancreatic amylase breaks down the ___
carbs
procolipase most be activated by_____ to ____ to help break down lipids
trypsin; colipse
trypsinogen is activate by ____ and it becomes activate d in ______
enteropeptidases; duodenum
____ enzyme can further catalyses the reactions: trypsinogen to trypsosin, procarbboxypeptidases to phospholipase and phospholipase to phospholipase
trypisin
acidic chyme stimulates the release of ___
HCO3-
peptides in the duodenum stimulate the release of ___
enzymes
lipids (soap) in the duodenum stimulates the release of ___
HCO3
both secretin and CCK ____ (decrease/increas) gastric sole
decrees
SECRETIN STIMULATES THE ____ OF THE BILE AND THE CCK STIMULATES THE ___ FROM THE VISUAL FELLING
release