Formation of the Nervous System Flashcards
How long is the pre-embryonic stage?
Conception to day 14
What is the single cell that divdies into multiple cells forming a solid sphere of cells as it travels down the fallopian tube into uterine cavity?
Fertilized Ovum
What is formed when there is a hollow of cells with innter cell mass becoming an embryo?
Cavity
What does the outermost layer of sphere in pre-embryonic stage become?
Placenta
What does the inner cell mask become during the pre-embryonic stage?
Embryonic disk
What are the 2 layers of the embryonic disk?
- endoderm
- ectoderm
What layer is formed between endoderm and ectocerm during pre-embryonic stage?
Mesoderm
When does the first stage of development occur in gastrulation?
3rd gestational week
What does the bilaminar disk embryonic disk become during gastrulation?
Trilaminar embryonic disk
What are the 3 layers of the trilaminar embryonic disk?
- ectoderm
- mesoderm
- endoderm
What layer of the trilaminar embroyonic disk is this?
develop sensory organs, epidermis and nervous system
Ectoderm
What layer of the trilaminar embroyonic disk is this?
Develops dermis, muscles, skeleton and excretory and circulatory systems
Mesoderm
What layer of the trilaminar embroyonic disk is this?
develops gut, liver, pancreas and respiratory system
Endoderm
What is the process that results in formation of the neural tube
Neurulation
When does neurulation occur?
4th gestational week
What is neurulation induced by?
Notochord
What is the longitudinal thickening of ectoderm; first formed on surface of embryo expanding from head to tail regions
Neural plate
What are the edges of plate folded upward; creates the neural groove
Neural folds
Where does the fushion of the neural tube occur?
occurs from middle out towards rostral and caudal ends
- cells on top of each fold dissociate
- cells with migrate away from tube and form various types of cells
- as tube closes is seperates from ectodermal surface
What is the openings on the ends of neural tubes; will eventually close
Neuralpores
When does the superior neuropore close?
27th day
When does the inferior neuropore close?
3 days after the superior neuropore close (30th day)
What layer of the neural tube is this?
Somas, cell bodies of neurons, and develop into gray matter
Inner layer
What layer of the neural tube is this?
White matter containing processes of neurons comprising of axons of glia cells
Outer layer
What does the rostral end of the neural tube become?
Brain
Which step of the formation of the neural tube is this?
- notochord includes ectoderm to differentiate and thicken into neural plate
- neural plate border seperates ectoderm from neural plate
Step 1: Neural plate formation
Which step of the formation of the neural tube is this?
- neural plate bends dorsally forming the neural groove and folds
- neural palte border develops into neural crest
Step 2: Neural grooves and folds formation
Which step of the formation of the neural tube is this?
- neural folds join at neural plate borders (neural crest) forming the neural tube
- neural crest disconnects from the epidermis
- neural crest cells differentiate to form PNS
Step 3: Neural tube formation
What is developed in the 3rd gestational week when columns divide into segmentated blocks of mesoderm
- appear in occipital region adjacent to neural groove
- added from rostral - to - caudal direction
Somite
What layer of the somite is this?
Lateral part of somite, dermatome that develops into dermis of skin
Outermost layer
What layer of the somite is this?
Postermedial region is the myotome
Myoblasts devlop into striated skeletal muscle
Middle layer
What layer of the somite is this?
Anteromedial part is the scelrotome
gives rise to bone, vertebrae and skull
Innermost layer
What cell is this?
Surrounds neural tube and notochord developing into the body of vertebrae forming vertebral arches (arches fuse at 8 weeks)
Sclerotome cells