F - Pharmacology of the ANS - Kruse

Question 1

Cholinomimetic agents

Answer 1

Drugs that mimic ACh
AChR agonists
Acetylcholinesterase inhibitors

Question 2

Sympathomimetic agents

Answer 2

Mimic or enhance a- and B-receptor stimulation

Enhance catecholamine release, drugs that block reuptake

Question 3

Adrenoceptor-blocking drugs

Answer 3

a and B-receptor agonists

Question 4

Radial m.

Answer 4

a1

Question 5

Ciliary m.

Answer 5

B2

Question 6

SA node

Answer 6

B1

Question 7

Lungs receptor

Answer 7

B2

Question 8

Parasympathetic System

Answer 8

Craniosacral
Rest and digest
NT: ACh
Receptors - mAChR

Question 9

Sympathetic System

Answer 9

Thoracolumbar
Fight or flight
NT: NE > Epi (DA); ACh
Receptors - a, B, nAChR, mAChR (sweat glands)

Question 10

M2 Characteristics

Answer 10

Cardiac

Gi - inhibitory - decrease cAMP

Question 11

Catecholamine synthesis

Answer 11

Tyrosine -> Dopa -> Dopamine -> NE -> Epinephrine
3 That occur in the cytoplasm - tyrosine - dopa - dopamine
2 that occur in the adrenal medulla - NE, epi

Question 12

VMAT-2

Answer 12

Transports NE, Epi, DA and serotonin into vesicles (promiscuous)

Question 13

NE transporter

Answer 13

NET

DAT imports DA into nerve terminal

Question 14

2 enzymes for metabolism of catecholamines

Answer 14

MAO - monoamine oxidase

COMT - catechol-O-methytransferase

Question 15

Which receptor causes lots of Ca2+ to be released?

Answer 15

a1 - smooth muscle contraction

Question 16

Receptor for lipolysis

Answer 16

B3

Question 17

Receptor for vascular smooth muscle relaxation?

Answer 17

B2

Question 18

Muscarinic receptors

Answer 18

Contract smooth muscle

-different intracellular signal than a1 receptors

Question 19

ACh and muscarinic agonists given IV cause

Answer 19

Vasodilation due to release of NO

Question 20

Blood vessels are innervated by________, which cause?

Answer 20

Adrenergic receptors

Constriction

Question 21

Is the smooth muscle of blood vessels innervated by parasymp?

Answer 21

NO

• mAChR nor nAChR found on them
• blood vessels relax in response to parasymp release of ACh as long as the epithelium is intact

Question 22

Activation of mAChRs on epithelial cells causes production and release of

Answer 22

EDRF (endothelium-derived relaxing factor)
AKA NO
Same as nitroglycerine

Question 23

Adrenal medulla

Answer 23

Sympathetic
80% Epi
20% NE