F - Pharmacology of the ANS - Kruse Flashcards
Cholinomimetic agents
Drugs that mimic ACh
AChR agonists
Acetylcholinesterase inhibitors
Sympathomimetic agents
Mimic or enhance a- and B-receptor stimulation
Enhance catecholamine release, drugs that block reuptake
Adrenoceptor-blocking drugs
a and B-receptor agonists
Radial m.
a1
Ciliary m.
B2
SA node
B1
Lungs receptor
B2
Parasympathetic System
Craniosacral
Rest and digest
NT: ACh
Receptors - mAChR
Sympathetic System
Thoracolumbar
Fight or flight
NT: NE > Epi (DA); ACh
Receptors - a, B, nAChR, mAChR (sweat glands)
M2 Characteristics
Cardiac
Gi - inhibitory - decrease cAMP
Catecholamine synthesis
Tyrosine -> Dopa -> Dopamine -> NE -> Epinephrine
3 That occur in the cytoplasm - tyrosine - dopa - dopamine
2 that occur in the adrenal medulla - NE, epi
VMAT-2
Transports NE, Epi, DA and serotonin into vesicles (promiscuous)
NE transporter
NET
DAT imports DA into nerve terminal
2 enzymes for metabolism of catecholamines
MAO - monoamine oxidase
COMT - catechol-O-methytransferase
Which receptor causes lots of Ca2+ to be released?
a1 - smooth muscle contraction
Receptor for lipolysis
B3
Receptor for vascular smooth muscle relaxation?
B2
Muscarinic receptors
Contract smooth muscle
-different intracellular signal than a1 receptors
ACh and muscarinic agonists given IV cause
Vasodilation due to release of NO
Blood vessels are innervated by________, which cause?
Adrenergic receptors
Constriction
Is the smooth muscle of blood vessels innervated by parasymp?
NO
- mAChR nor nAChR found on them
- blood vessels relax in response to parasymp release of ACh as long as the epithelium is intact
Activation of mAChRs on epithelial cells causes production and release of
EDRF (endothelium-derived relaxing factor)
AKA NO
Same as nitroglycerine
Adrenal medulla
Sympathetic
80% Epi
20% NE
