Exam Three - Plasticity Flashcards

1
Q

neuroplasticity

A

the ability of the brain to change and adapt itself as a result of one’s experience

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2
Q

the process of experience dependent changes in synaptic connectivity is called

A

synaptic plasticity

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3
Q

10 principles of neuroplasticity

A

1 - use it or lose it
2 - use it and improve it
3 - specificity
4 - repetition matters
5 - intensity
6 - time
7 - slience
8 - age
9 - generalization
10 - interference

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4
Q

4 ways for the brain to change

A

1 - neurogenesis
2 - synaptogenesis
3 - strengthened synapses LTP
4 - weakened synapses LTD

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5
Q

3 primary vesicles of brain development

A

prosencephalon, mesencephalon, rhombencephalon

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6
Q

what are the secondary brain vesicles

A

telencephalon, diencephalon, mesencephalon, metencephalon, myelencephalon

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7
Q

the development of neurons in the brain involved these 6 processes

A

1 - proliferation
2 - migration
3 - differentiation
4 - pruning
5 - myelination
6 - synaptogenesis

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8
Q

proliferation

A

production of new cells/neurons primarily occurs early in life

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9
Q

migration

A

movement of newly formed neurons to their eventual location **radial glia help guide the neurons

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10
Q

differentiation

A

forming of the axon and dendrites

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11
Q

do axons or dendrites grow first

A

axons

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12
Q

programmed cell death/pruning results from..

A

a surplus of neurons relative to target

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13
Q

where does myelination occur first

A

spinal cord

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14
Q

neurogenesis ->__________ -> competitive inhibition

A

synaptogenesis

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15
Q

this occurs during synaptogenesis and competitive elimination

A

dendritic and axonal arborization

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16
Q

monocular deprivation experiment

A

one eye of a newborn kitten was closed after birth for 2 months. no cells received input from both eyes while the control group did. connections between the good eye and the brain became stronger

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17
Q

what was the conclusion of the monocular deprivation experiment

A

deprivation of one eye early in life lead to a physical rewiring of the brain

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18
Q

what neurotransmitter triggers the onset of critical periods

A

GABA

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19
Q

what age is the end of the critical periof

A

5

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20
Q

multimodal association areas in ________, ________, and _______- lobes mature last

A

parietal, frontal, temporal

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21
Q

this is important for learning and memory by converting short term memory to more permanent memory

A

hippocampus

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22
Q

T or F: the hippocampus is for storage

A

false

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23
Q

these 3 things control emotional or behavioral memories

A

amygdala, striatum, cerebellum

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24
Q

declarative memory

A

the cognitive information retrieved from explicit memory, knowledge that can be declared

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25
Q

2 types of declarative memory

A

semantic and episodic

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26
Q

semantic memory

A

cultural knowledge, ideas, and concepts about the world, such as word definitions, how to add or subtract, name of capitals, dates of historical events and their meaning

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27
Q

episodic memory

A

unique representations of personal experiments

28
Q

this is a temporary form of declarative memory

A

working memory

29
Q

what are the stages of memory

A

sensory, short term, long term

30
Q

this provides neural basis for short term memory

A

reverberating circuits

31
Q

the prefrontal cortex is anterior to _______ and ______ cortex

A

primary motor and premotor

32
Q

function of prefrontal cortex

A

executive functions, planning, decision making, personality, social behavior

33
Q

T or F: spatial memory is a form of declarative memory

A

true

34
Q

spatial memory

A

memory for the physical environment, it includes things such as location of objects, direction, and cognitive maps

35
Q

place cells

A

neurons maximally responsive to specific locations in the worldt

36
Q

these cells are pyramidal neurons in the dorsal hippocampus

A

place cells

37
Q

grid cells

A

entorhinal neurons that allow brain to track position in space when external cues are absent

38
Q

______- cells know the location while ____ cells know how to get from one place to another

A

place, grid

39
Q

T or F: grid cells represent locations

A

F

40
Q

CA1 is the first region in the hippocampal circuit and gives output to the entorhinal cortex via

A

subiculum

41
Q

CA2 receives input from the entorhinal cortex via the

A

perforant path

42
Q

CA3 receives input from

A

mossy fibers of the granule cells in the dentate gyrus

43
Q

this is the pacemaker of the hippocampus

A

CA3

44
Q

CA3 project to regions CA2 and CA1 via

A

schaffer collaterals

45
Q

long-term potentiation

A

gradual strengthening of the connections among neurons from repetitive stimulation
Fire together wire together

46
Q

long term depression

A

a long-term decrease in the excitability of a neuron to a particular synaptic input caused by stimulation of the terminal button while the postsynaptic membrane is hyperpolarized or only slightly depolarized
fire out of sync, lose the link

47
Q

encoding new long term memory involved persistent changes in (5)

A

1 - number of synapses
2 - shape of synapses
3 - amount of neurotransmitter release
4 - number of receptors on the postsynaptic membrane
5 - gene expression that facilitates long term changes in synaptic structure

48
Q

CREB

A

protein that can switch genes on/off with memory and connection of memories

49
Q

memory consolidation consists of these 2 specific processes

A

synaptic consolidation
system consolidation

50
Q

declarative memories are encoded in the ___ then transferred to the ________ lobe for long term storage and consolidation

A

hippcampus
frontal

51
Q

what are some possible causes of brain damage

A

1 - tumors
2 - infections
3 - exposure to toxic substances
4 - neurodegenerative disorders
5 - stroke
6 - close head injuries

52
Q

3 types of strokes

A

ischemia, embolic, hemorrhagic

53
Q

T or F: some mechanisms of recovery after damage are similar to mechanisms of brain development

A

T

54
Q

T or F: If the soma is damaged it can be replaced

A

F: apoptosis occurs

55
Q

2 barriers to axonal growth after CNS injury

A

glia scar
myelin associated inhibitors

56
Q

Tor F: CNS axons grow back quicker than PNS

A

F

57
Q

Axonal sprouting

A

undamaged axons grow new nerve endings to reconnect neurons whose links were injured or severed

58
Q

after damage postsynaptic cells deprived of synaptic inputs develop _________ to neurotransmitters

A

increased sensitivity

59
Q

denervation hypersensitivity

A

sharp increase of sensitivity to postsynaptic membranes to neurotransmitters after denervation

60
Q

disuse hypersensitivity

A

target cells on losing neural input through either denervation or chronic application of an antagonist, produce more than the normal number of receptors, resulting in an exaggerated response when a neurotransmitter is applied

61
Q

phantom pain caused by

A

map expansion neuroplasticity in which local brain regions acquire areas of unused phantom map

62
Q

difference in repaire/regeneration in the CNS vs PNS

A

PNS = axon regeneration, growth factors from schwann cells
CNS = gets rid of axon, growth inhibiting factors

63
Q

Oligodendrocytes in the CNS do not promote growth and secrete a growth inhibiting factor when damaged called

A

NOGO-A

64
Q

T or F: mature differentiated neurons divide

A

F

65
Q

in mammals new nerve cell production is restricted to these 2 areas

A

1 - olfactory bulb
2 - dentate gyrus of the hippocampus
Note: all are interneurons