Exam 6-OsteoDystrophy-Metabolic, Unknown & Other Causes Flashcards
What is the term for a Vitamin D deficiency during INFANCY?
Rickets
What is the term for a VItamin D deficiency during ADULTHOOD?
OsteoMALACIA
Rickets in infancy presents with growth retardation, prominence of the costochondral junctions (rachitic _____),
_____ of the legs
rosary and bowing
Osteomalacia presents with weak bone, _______ , diffuse skeletal pain
fractures
What is culprit for 80-90% of Hyperparathyroidism cases?
a parathyroid adenoma
What age and sex presents with hyperparathyroidism most frequently?
Women over 60
The mechanism for Parathyroid Hormone is to increase blood calcium which causes bone ______
resorption
What is the typical cause of secondary hyperparathyroidism?
chronic renal disease
Mechanism for secondary hyperparathyroidism: vit D does not get activated by the ______, absorption of ______ does not happen in the intestine and PTH is increased
kidney…calcium
What is our cute little rhyme for the mainfestations of hyperparathyroidism?
Stones, bones, and abdominal groans (kidney stones, calcifications)
Oral Radio features of hyperparathyroidism: loss of _______, ________ trabecular pattern, _____ tumor (radiolucency)
lamina dura, ground glass, brown
Which metabolic osteodystropic disease is associated with BROWN tumors? What do they appear as in a radiograph?
hyperparathyroidism…radioLucent
What is the Histo of a BROWN tumor INDISTINGUISHABLE from?
a Giant cell granuloma
Renal osteodystrophy is a complication of ________ hyperparathyroidism in end stage renal disease
SECONDARY
What is the radiographic feature of renal osteodystrophy?
ground glass pattern
What is the oral manifestation of renal osteodystrophy?
enlargement of the jaws
What is the histology of a lesion assocuated with a renal osteodystrophy?
fibro-osseus lesion
Which form of osteodystrophy presents with accelerated resorption and deposition of bone, ultimately osteoblasts win and bones become sclerotic, larger and brittle?
Paget’s disease of bone
In Paget’s disease of bone: Accelerated resorption and deposition of bone, ultimately WHICH TYPE OF CELL wins?? and bones become sclerotic, larger and brittle
OSTEOBLASTS
What is the typical demographic for Paget’s disease of the bone?
White males over 40
Is Paget’s disease of bone typically associated with one bone affected or multiple bones affected?
PolyOstotic (multiple)
Paget’s disease of bone CAN be asymptomatic, but if it is showing symptoms it is most likely WHAT?
bone pain
What are the two etiologies associated with Paget’s Disease of Bone?
1.ParaMyxoVirus infection 2.genetic
Radiographically, Paget’s disease of bone can vary from well defined radiolucent to mixed radioluct/opaque to “________” type of Radiopaque
“Cotton Wool-like”
What is the ORAL manifestation of Paget’s Disease of Bone?
generalized HYPERCEMENTOSIS
What is the most important complication of Paget’s Disease of Bone? (what is a lesser concern?)
1 OSTEOGENIC SARCOMA (maligant transformation) 2-fractures
Fibrous Dysplasia affects differentiation of What type of cell?
preosteoblasts
Which osteodysplasa is characterized by bones that become replaced with fibrous tissue and immature bone?
Fibrous Dysplasia
What % range of Fibrous Dysplasia is monOstotic?
80-85%
What are the distinuishing features of Fibrous Dystplasia-Jaffe-Lichtenstein Syndrome style?
Polyostotic with cafe au lait spots
What are the distinuishing features of Fibrous Dystplasia-McCune-Albright Syndrome style?
Polyostotic with cafe au lait AND endocrineopathy
Which flavor of Fibrous dysplasia is this describing? Polyostotic with café au lait AND endocrinopathy
McCune-Albright Syndrome
Which flavor of Fibrous dysplasia is this describing? Polyostotic with café au lait
Jaffe-Lichtenstein Syndrome