Exam 6- Lymphoepithelial Sialadenitis

Question 1

PEN AND PAPER: What are the 4 examples given for Lymphoepithelial sialadenitis?

Answer 1

1.MyoEpithelial Sialadenitis 2.Benign LymphoEpithelial Lesion 3.Mik-UL-icz disease 4.Sjogrens Syndrome

Question 2

LymphoEpithelial sialadenitis is a ________ condition of salivary glands producing asymptomatic ______

Answer 2

NON-neoplastic….SWELLING

Question 3

Which sex is more affected by lymphoepithelial sialadenitis? What age range?

Answer 3

females 3:1…4-7th decade (aunt sue and her sjogrens)

Question 4

What gland does 90% of lymphoepithelial sialadenitis affect? Occasionally which other gland??

Answer 4

parotid..submandibular

Question 5

Lymphoepithelial sialadenitis is not synonymous with _________ but most patients with this condition have lymphoepithelial sialadenitis…chew on that one…

Answer 5

Sjogrens Syndrome

Question 6

The histopathology of lymphoepithelial sialadenitis shows inflammatory/immune infiltrates that REPLACE salivary acini and residual ducts showing squamous ________

Answer 6

METAplasia

Question 7

Sjogrens-________ disease mainly affects ______ and ______ glands

Answer 7

autoimmune…salivary and lacrimal

Question 8

What % of sjogrens syndrome affects FEMALES?

Answer 8

80-90%

Question 9

What is Primary sjogrens mean?

Answer 9

no other autoimmune disease

Question 10

What does secondary sjogrens mean?

Answer 10

associated with other autoimmune diseases (RA, SLE)

Question 11

How many of the 6 diagnostic tests have to be positive for there to be a diagnosis of sjogrens?

Answer 11

4/6 (1.dry eye 2.dry mouth 3.saliva flow test 4.ocular test 5.biopsy 6.blood test

Question 12

What is the GOLD standard for diagnosing sjogrens syndrome?

Answer 12

Oral Labial Biopsy

Question 13

WHAT IS THE BIGGEST thing we need to MONITOR for patients with Sjogrens?

Answer 13

40x increased risk for LYMPHOMA! (MALT-marginal zone lymphoma)

Question 14

What is a Multi-system granulomatous disorder of unknown cause?

Answer 14

SAR-COID-OSIS

Question 15

SarCoidOsis is a Multi-system __________ disorder of UNKNOWN cause

Answer 15

granulomatous

Question 16

What are the demographics for SarCoidOsis? (age,race,sex)

Answer 16

20-40 y/o, black, female

Question 17

SarCoidOsis Affects lungs, lymph nodes, skin, eyes and WHAT?

Answer 17

salivary glands

Question 18

What % of sarcoidosis is ASYMPTOMATIC?

Answer 18

20%

Question 19

SarCoidOsis is diagnosed by clinical findings, _____ radiographs (bilateral hilar lymphadenopathy), biopsy, ↑ serum _____ (Angiotensin converting enzyme)

Answer 19

chest…ACE

Question 20

What two syndromes are related to SarCoidOsis?

Answer 20

Lofgren’s syndrome and Heer-fordT’s syndrome

Question 21

What is the distunishing characteristic in Lofgren’s syndrome?

Answer 21

Bilateral Hilar Lymph-Adenom-Pathy

Question 22

What is the distinguishing characteristic in HeerFordT’s syndrome?

Answer 22

parotid enlargement (facial paralysis)

Question 23

What is another name for FREY syndrome?

Answer 23

AuriculoTemporal Syndrome

Question 24

WHEN do flushing, sweating, warmth in preauricular and temporal skin occur during FREY syndrome?

Answer 24

while CHEWING!

Question 25

What are the three types of nerves affected in Frey syndrome? (Think nerve supply to parotid)

Answer 25

1.sensory 2.sympathetic 3.parasympathetic (FREY’s syndrome, the wiring to the parotid is FREYED and mixed up)

Question 26

More than ___% of patients with PAROTIDECTOMIES develop Frey syndrome

Answer 26

40%