Exam 2-Non-Neoplastic Proliferations Flashcards
Patients commonly present with swelling (_________). This can be the result of _________, a ______ lesion or a ________ lesion (either benign or malignant).
TUM–E–faction…inflammation… reactive…. neoplastic
_______ tumors are usually the result of hyperplasia which is due to an increase in the number of normal cells
REACTIVE
Reactive tumors are usually the result of _________ which is due to an increase in the number of normal cells
hyperplasia
Reactive tumors are usually the result of hyperplasia which is due to an increase in the number of ______ cells
NORMAL
While reactive tumors can become quite large, they are not considered to have “unlimited _________” like neoplasms
growth potential
reactive tumors are thought to be the result of the body’s reaction to a stimulus (often ______ irritation)
physical
Reactive lesions constitute about ___% of all lesions biopsied in a dental office.
20%
________ lesions constitute about 20% of all lesions biopsied in a dental office.
REACTIVE
_______: Hyperplasia of fibrous connective tissue
fibroma
WHAT IS THE MOST COMMON TUMOR OF THE ORAL MUCOSA?
FIBROMA!!
What am I describing?? usually sessile, smooth surfaced, normal color, asymptomatic
Fibroma
Where are fibroma’s most often found?
Cheek, but can be found everywhere
What is the variant that you DON’T want to confuse with a giant cell granuloma?
Giant Cell Fibroma
What can a Giant Cell Fibroma be sometimes confused with in name? WHAT ABOUT CLINICALLY??
A Giant cell granuloma…Clincially: Papilloma
________: “papillary” tumor of fibrous connective tissue containing plump, stellate and often bi or trinucleated fibroblasts
Giant Cell Fibroma!
Which age group is most susceptible to Giant Cell fibromas?
Children
What are the two most common areas to find a Giant Cell Fibroma?
- Gingiva 2.Tongue
What is a reactive, fibroblastic lesion of PDL?
Peripheral Odontogenic (Ossifying) Fibroma
What is the most common age range for a Peripheral Odontogenic (Ossifying) Fibroma?
10-30 years old
Where is the ONLY place a Peripheral odontogenic (ossifying) fibroma occurs?
The gingiva (PDL)
What are the symptoms associated with a Peripheral Odontogenic (Ossifying) Fibroma?
HAHA GOT YA! NONE…Asymptomatic
What could I be describing??: pedunculated or sessile mass ± red ± ulceration
Peripheral Odontogenic (Ossifying) Fibroma
What am I describing?: Histology: Cellular fibroblastic lesion with bone and/or cementum and/or dystrophic calcification
Peripheral Odontogenic (Ossifying) fibroma
What is the treatment for a Peripheral Odontogenic (Ossifying) Fibroma?
Excision, including superficial PDL
WHICH REACTIVE GINGIVAL LESION HAS HIGHEST RECURRENCE RATE? What is the rate?
Peripheral Odontogenic (Ossifying) Fibroma…15-20% recurrence rate
What is another name for Inflammatory Fibrous Hyperplasia?
Epulis Fissuratum
What are reactive folds of hyperplastic fibrous connective tissue along border of ill-fitting, over extend denture (2 names please)
1.Inflammatory Fibrous Hyperplasia 2.Epulis Fissuratum
What is the histology of an epulis fissuratum (inflammatory fibrous hyperplasia)?
lol…fibrous hyperplasia and inflammation (I wonder how it got its name??)
What is the treatment for Inflammatory fibrous hyperplasia (aka. epilus fissuratum)
excision and reline (or remake) the denture
What is another name for Inflammatory Papillary Hyperplasia?
Papillamatosis
What is classified as a hyperplastic response of palatal mucosa to ill-fitting denture
Inflammatory Papillary Hyperplasia (papillamatosis)
What is the fancy term for the histology of a Inflammatory Papillary Hyperplasia?
Pseudo-Epithel-io-matous Hyperplasia (PEH)
What is the treatment for Inflammatory Papillary Hyperplasia?
Excise, remake/reline
What is a Tumor of well vascularized fibrous connective tissue containing numerous multinucleated giant cells?
Peripheral Giant Cell Granuloma
What is the most common site for a Peripheral Giant Cell Granuloma?
the anterior gingiva
What is the typical age for the occurrence of a peripheral giant cell granuloma? What are the typical symptoms?
any age, asymptomatic
Which type of lesion can be a usually reddish-brown-purple pedunculated or sessile mass
Peripheral Giant Cell Granuloma
Who is affected more by peripheral giant cell granulomas: males or females?
females 2:1!!
Which type of lesion may produce cupping resorption of underlying bone?
Peripheral Giant Cell Granuloma
Treatment of a Peripheral Giant Cell Granuloma: Excision and removal of irritants, may DO WHAT?
RECUR!
Why is a pyogenic granuloma a misnomer?
because its not a pus producing lesion…its a reactive lesion made of granulation tissue
What lesion is reddish, ulcerated pedunculated or sessile mass?
Pyogenic Granuloma
What are the most common age ranges for a Pyogenic Granuloma and where is the most common site for one? WHAT ARE THE SYMPTOMS?
20-40 years old and on the gingiva…Asymptomatic but may bleed easily (I THINK I HAVE ONE OF THESE!!)
What lesion has the nickname of “pregnancy tumor”?
Pyogenic Granuloma
What is a pyogenic granuloma called in an extortion socket?
Epilus Granulomatosa
This is the histology of WHAT type of non-neoplastic proliferation???: Hyperplastic granulation tissue, fibroblasts with delicate collagen, endothelial cells + capillaries and dilated larger vessels
Pyo-genic Granuloma
Can a pyogenic granuloma recur if it is excised?
Yep!
What is another name for a gum boil?
“Parulis”
Hmmm…WTF am I talkin’ bout? Can occur anywhere but on gingiva, it represents draining from a source of odontogenic infection of either pulpal or periodontal origin pus (purulence, suppuration) = bacterial infection
A Parulis/Gum Boil
Holy shit, what is the 5 word name for this indication: Localized hyperplasia presumably from externalized sulcular epithelium on gingiva….(typically in JUVENILES!)
Localized juvenile spongiotic gingival hyperplasia
Localized juvenile spongiotic gingival hyperplasia: ALMOST EXCLUSIVELY in what age range and what sex?
10-30 y/o and 2:1 female
Localized juvenile spongiotic gingival hyperplasia: almost all ________ gingiva, and which arch is more likely?
anterior….maxillary arch
Localized juvenile spongiotic gingival hyperplasia: WHAT COLOR?… often _______ gingival lesions
RED…. papillary
WHO AM I? (I don’t know) Papillary proliferation of inflamed epithelium with intercellular edema (spongiosis)
Localized juvenile spongiotic gingival hyperplasia:
What is an Overgrowth of blood vessels ?
Hemangioma
(________– localized overgrowth of tissues native to the part, often developmental)
hamartoma
HEMANGEOMA is a rapid proliferation of WHAT TYPE OF cells at birth or shortly thereafter, characteristically INVOLUTE (whatever the f that means)
ENDOTHELIAL
**What is the most common tumor of infancy?!?
Hemangioma (5-10%) incidence
What sex is more likely to have a HE-MAN-geoma? What % of these are in the Head and Neck?
Females (3:1)…60% are Head and Neck
When is the MOST likely age range for a HE-MAN-gioma to develop? They are 90% developed at what age?
0-5 years…90% by age 10
Is a He-Man-gioma congenital?
RARELY congenital!
What is a reddish to purple mass lesions that tend to blanch with pressure?
Hemangioma
What is UNIQUE about an ORAL hemangioma?
they develop later in life and don’t involute
Which NON-Neoplastic Proliferation can occur in BONE, often multilocular or soap bubble appearance (why you aspirate before bone biopsy)???
Hemangioma
Which non-neoplastic proliferation histologically has Endothelial cell proliferation with formation of small capillaries (capillary) or larger dilated vascular spaces (cavernous)?
Hemangioma
What non-neoplastic proliferation is treated via these methods: Natural history is INVOLUTION laser pulse, excision, sclerosing agents, steroids both intralesional and systemic, propranolol
Hemangioma
WTF is this?? Nonhereditary developmental, congenital condition characterized by vascular proliferation of brain and face usually along distribution of ophthalmic branch of the trigeminal nerve??
STURGE-WEBER ANGIO-MAT-OSIS
What is the scientific name for Sturge-Weber Angiomatosis? (think of its location!!)
Encehpalo-Trigeminal Angiomatosis
Is Sturge-Weber hereditary?
Non-hereditary
Is Sturge-Weber congentical?
Yes, it is congenital
THIS IS….AWESOME!!!! Sturge-Weber and port wine stains are due to somatic activation mutation in _____ which encodes Gαq, a member of the q class of ________ alpha subunits that mediates signals between ________–coupled receptors and downstream effectors. The difference is when and where the mutation occurs
GNAQ….G-Protein..G-PROTEIN
Sturge-Weber: Large WHAT COLOR lesions –identical clinically to ________ stains, (IPSILATERAL or CONTRALATERAL) oral mucosal involvement common leptomingeal angiomas of cerebral cortex
Purplish…port-wine…IPSILATERAL
You better not get this shiz wrong: What is a developmental overgrowth of lymphatic vessels?
Lymphangioma
Where are the most common regions for lymphangioma and what age are they most common in?
head and neck….0-5 years
Where is the most common place for a lymphangioma in the mouth?
on the TONGUE!!
What type of tongue pathology can be the result of lymphangioma
MACROglossia
A superficial lymphangioma is likely to have a _____ surface with translucent vesicles.
pebbly
Are deeper lymphangiomas of the tongue more concentrated or more diffuse?
more diffuse
What is the VARIANT of a Lymphangioma that infiltrates and becomes VERY large (↑ neck)?
Cystic Hy-GRO-ma
This is the Histology of WHAT? Proliferation of thin walled lymphatic vessels capillary sized, Dilated (cavernous) or cystically dilated (cystic hygroma)
Lymphangioma
This is the treatment for WHICH non-neoplastic proliferation: Lesions don’t involute, Excision, Deeper ones often recur, Sclerosing agents
Lymphangioma
