Exam 3-Lymphoma, Myeloma, Leukemia Flashcards

1
Q

What are Malignancies of immune system?

A

lymphoma (mostly affecting lymphocytes)

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2
Q

Lymphomas tend to have lymphadenopathy where nodes are firm, ______, PAINLESS, movable or fixed (inflammatory nodes are painful or tender). Tend to be multifocal.

A

RUBBERY

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3
Q

Which type of lymphoma is POSTIVE for REID-STERNBERG cells?

A

Hodgkins disease

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4
Q

In hodgkins disease, what % of lymphadenopathies are going to present cervially or supraclavicularly? Is oral involvement rare or common?

A

75%…more rare

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5
Q

How many sub-types of Hodgkins are there?

A

4

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6
Q

For staging of Hodgkin’s: single extra lymphatic organ or site

A

stage I

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7
Q

For staging of Hodgkin’s: two or more lymph nodes on one side of the diaphragm

A

Stage II

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8
Q

For staging of Hodgkin’s: both sides of diaphragm

A

Stage III

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9
Q

For staging of Hodgkin’s: diffuse

A

stage IV

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10
Q

For staging of Hodgkin’s: What does Type A or B mean?

A

A-asymptomatic…B-fever, weight change

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11
Q

If its Stage I or II hodgkin’s they may just treat with this one tx:

A

radiation…stages III,IV they’ll do chemo

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12
Q

Hodgkin’s is considered a great success, Stage I and II 5 year survival is over ___%

A

90%

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13
Q

Which type of lymphoma is diverse group of immune system malignancies, usually B cell origin, but some T-cell and occasionally histolytic?

A

Non-hodgkin’s

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14
Q

Non-Hodgkin’s is typically ____ cell origin

A

B

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15
Q

Which type of hodgkin’s tends to spread more unpredictably and often affects non lymphoid tissues?

A

non-hodgkin’s

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16
Q

Which type of disease commonly affects the hard palate?

A

NON-hodgkin’s

17
Q

Burkitt’s Lymphoma is a type of _______ __-cell lymphoma

A

NON-hodgkin’s B-cell lymphoma

18
Q

What % of Burkitt’s lymphoma-african jaw lymphoma contains the EPSTEIN BARR Virus? What do 80% of these show genetically?

A

90%..translocation of an oncogene

19
Q

Which type of lymphoma does the lesion grow so rapidly that you can see it change size in 48hrs?

A

Burkitt’s lymphoma

20
Q

Which type of lymphoma has the classic “starry sky” phagocytic cells interspersed in a sea of malignant lymphoid cells?

A

Burkitt’s lymphoma

21
Q

Burkitt’s lymphoma Histologically shows “Starry sky”, Which is _________ cells interspersed in sea of small malignant lymphoid cells

A

phagocytic cells

22
Q

Burkitt’s lymphoma must be treated with Aggressive chemotherapy, usually with ___________

A

cyclo-phosph-amide

23
Q

What is the most common malignancy of bone?

A

Multiple Myeloma

24
Q

What is the relationship between multiple myeloma and age? Sex?

A

mm increases w age and more in males

25
Q

What is a classic clinical sign of multiple myeloma?

A

bone pain! (anemia, fatigue)

26
Q

Multiple myeloma will often display this: ________ in the blood, which is where there is a prevalence of one type of antibody being produced over and over.

A

Monoclonal Gammopathy

27
Q

What are two key radiographic features of multiple myeloma?

A

1.orally destructive lucency’s (cortex destroyed) 2.skull punched out lucency’s

28
Q

What is the 5 yr survival % for multiple myeloma?

A

:( 33%

29
Q

What is a SINGLE bone lesion of myeloma?…many patients will develop __________

A

solitary myeloma….multiple myeloma

30
Q

What are Soft tissue lesions caused by malignant plasma cells?? (hint: it can be isolated or WITH multiple myeloma)

A

EXTRA-MEDULLARY PLASMA-Cytoma

31
Q

What is a malignancy of bone marrow stem cells?

A

Leukemia

32
Q

What are the 3 classes of Leukemia?

A

1.Myelocytic 2.Lymphocytic 3.Monocytic

33
Q

What is the PRIMARY ORAL manifestation of leukemia??

A

Generalized GINGIVAL ENLARGEMENT

34
Q

What are the 4 classic oral secondary manifestations of leukemia?

A

1.anemia 2.thrombocytopenia (BLEEDING @ gingival sulcus) 3.immunosupression-lots of oral infections 4.PALATAL PETEKIAE