Exam 3-Lymphoma, Myeloma, Leukemia Flashcards
What are Malignancies of immune system?
lymphoma (mostly affecting lymphocytes)
Lymphomas tend to have lymphadenopathy where nodes are firm, ______, PAINLESS, movable or fixed (inflammatory nodes are painful or tender). Tend to be multifocal.
RUBBERY
Which type of lymphoma is POSTIVE for REID-STERNBERG cells?
Hodgkins disease
In hodgkins disease, what % of lymphadenopathies are going to present cervially or supraclavicularly? Is oral involvement rare or common?
75%…more rare
How many sub-types of Hodgkins are there?
4
For staging of Hodgkin’s: single extra lymphatic organ or site
stage I
For staging of Hodgkin’s: two or more lymph nodes on one side of the diaphragm
Stage II
For staging of Hodgkin’s: both sides of diaphragm
Stage III
For staging of Hodgkin’s: diffuse
stage IV
For staging of Hodgkin’s: What does Type A or B mean?
A-asymptomatic…B-fever, weight change
If its Stage I or II hodgkin’s they may just treat with this one tx:
radiation…stages III,IV they’ll do chemo
Hodgkin’s is considered a great success, Stage I and II 5 year survival is over ___%
90%
Which type of lymphoma is diverse group of immune system malignancies, usually B cell origin, but some T-cell and occasionally histolytic?
Non-hodgkin’s
Non-Hodgkin’s is typically ____ cell origin
B
Which type of hodgkin’s tends to spread more unpredictably and often affects non lymphoid tissues?
non-hodgkin’s
Which type of disease commonly affects the hard palate?
NON-hodgkin’s
Burkitt’s Lymphoma is a type of _______ __-cell lymphoma
NON-hodgkin’s B-cell lymphoma
What % of Burkitt’s lymphoma-african jaw lymphoma contains the EPSTEIN BARR Virus? What do 80% of these show genetically?
90%..translocation of an oncogene
Which type of lymphoma does the lesion grow so rapidly that you can see it change size in 48hrs?
Burkitt’s lymphoma
Which type of lymphoma has the classic “starry sky” phagocytic cells interspersed in a sea of malignant lymphoid cells?
Burkitt’s lymphoma
Burkitt’s lymphoma Histologically shows “Starry sky”, Which is _________ cells interspersed in sea of small malignant lymphoid cells
phagocytic cells
Burkitt’s lymphoma must be treated with Aggressive chemotherapy, usually with ___________
cyclo-phosph-amide
What is the most common malignancy of bone?
Multiple Myeloma
What is the relationship between multiple myeloma and age? Sex?
mm increases w age and more in males
What is a classic clinical sign of multiple myeloma?
bone pain! (anemia, fatigue)
Multiple myeloma will often display this: ________ in the blood, which is where there is a prevalence of one type of antibody being produced over and over.
Monoclonal Gammopathy
What are two key radiographic features of multiple myeloma?
1.orally destructive lucency’s (cortex destroyed) 2.skull punched out lucency’s
What is the 5 yr survival % for multiple myeloma?
:( 33%
What is a SINGLE bone lesion of myeloma?…many patients will develop __________
solitary myeloma….multiple myeloma
What are Soft tissue lesions caused by malignant plasma cells?? (hint: it can be isolated or WITH multiple myeloma)
EXTRA-MEDULLARY PLASMA-Cytoma
What is a malignancy of bone marrow stem cells?
Leukemia
What are the 3 classes of Leukemia?
1.Myelocytic 2.Lymphocytic 3.Monocytic
What is the PRIMARY ORAL manifestation of leukemia??
Generalized GINGIVAL ENLARGEMENT
What are the 4 classic oral secondary manifestations of leukemia?
1.anemia 2.thrombocytopenia (BLEEDING @ gingival sulcus) 3.immunosupression-lots of oral infections 4.PALATAL PETEKIAE
