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ORAL PATHOLOGY! > Exam 5-NON-Infective stomatits PART 2 > Flashcards

Exam 5-NON-Infective stomatits PART 2 Flashcards

1
Q

What is described as having an acute onset, immune mediated blistering mucocutaneous condition?

A

Erythemia Multiforme

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2
Q

Erythema multiforme is NOT ________ but it is immune related

A

auto-immune

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3
Q

Erythema Multiforme is most often following _________ or often as a post infectious process, esp post _____.

A

systemic medications….VIRAL

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4
Q

Erythema Multiforme is self limiting and typlically clears in HOW LONG?

A

2-6 weeks

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5
Q

Erythema Multiforme affects skin and mucous membranes, rarely ONLY in the _______

A

mouth

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6
Q

What age range is typically affected by Erythema Multiforme? Is there a sex preference?

A

young adults in their 20s-30s and MALES affected more

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7
Q

Which virus is typically to blame for Erythema Multiforme?

A

Herpes simplex

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8
Q

Fever, malaise, headache, cough, sore throat are all ______ symptoms of Erythema Multiforme

A

prodromal

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9
Q

What is the recurrence rate of Erythema Multiforme?

A

20%

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10
Q

What is the most classic condition for manifestations of disease on PALMS and SOLES? What are two other possibilites?

A

The classic: erythema multiforme…..the other two-secondary syphilis and coxsackie A (hand-foot-mouth disease)

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11
Q

The condition is called MULTIFORM because the skin lesions are highly ______

A

variable

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12
Q

What are the two descriptors for the lesions of Erythema Multiforme?

A

TARGET or BULL’S EYE

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13
Q

Can Erythema Multiforme appear WITHOUT oral lesions?

A

YEP!

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14
Q

Erythema Multiforme: Oral ulcers with erythema and _______ borders

A

irregular

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15
Q

Holy S…the locations for Erythema Multiforme are labial mucosa, tongue, floor of mouth, soft palate and MOST COMMONLY ______ with crusting and bleeding at the ________

A

the LIPS with bleeding at the VERMILLON zone

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16
Q

What is the MOST SEVERE form of Erythema Multiforme?

A

Steven-Johnson Syndrome

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17
Q

Which condition shows extensive mucosal ulceration that also affects genital and OCULAR mucosa?

A

Steven-Johnson Syndrome

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18
Q

What is the usual trigger of Steven-Johnson Syndrome?

A

medications

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19
Q

Which complication of Steven-Johnson Syndrome makes it life threatening?

A

it can affect internal organs

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20
Q

WHAT IS THE MOST SEVERE FORM of Steven-Johnson syndrome?

A

TEN-Toxic Epidermal Necrolysis

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21
Q

What is the trigger for the MOST SEVERE form of Erythema Multiforme?

A

Toxic Epidermal Necro-Lysis is triggered by DRUG exposure

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22
Q

TEN-Toxic EpiDermal NecroLysis is shows diffuse sloughing of skin and mucosal surfaces and has a predilection for WHICH SEX?

A

FEMALE

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23
Q

After identifying the source of Erythema Multiforme, what is the treatment?

A

topical and SYSTEMIC high dose steriods (60mg prednisone)

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24
Q

What are the two other (probably more offical) names for Geographic Tongue?

A

Erythema migrans and benign migratory glossitis

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25
Q

Geographic tongue is an inflammatory tongue condition of WHAT TYPE OF ETIOLOGY?….its also relatively common (__-___% of population)

A

1-3% of the population

26
Q

Since we all know geographic tongue is more common in women than men, HOW much is it more common??

A

2x

27
Q

Geographic tongue rrimarily affects ______ and _____ borders of tongue

A

dorsal and lateral

28
Q

In geographic tongue depapillated areas that are erythematous or normal colored with characteristic WHAT 2 COLORED?? borders that marginate the lesions.

A

yellow-white

29
Q

GOOD TO KNOW: geographic tongue heals spontaneously and recur at different sites…its usually asymptomatic but occasional _______

A

BURNING

30
Q

What patients can see an increased incidence of Geographic tongue?

A

Psoriatic patients

31
Q

What is the treatment for geographic tongue?

A

no Tx necessary, but TOPICAL steroids if symptomatic

32
Q

What is a rare syndrome in which the oral lesions LOOK like geographic tongue and also comes with urethritis, arthritis, conjunctivitis?

A

REI_TERS Syndrome

33
Q

What is an autoimmune disease that is 8x more common in women and the average age is 31??

A

LUPUS ErythemaTOsus

34
Q

Lupus Erythematosus is an _________ disease that is _x more common in women and the average age is ___

A

autoimmune..8x…31

35
Q

What is the classic skin lesion of Lupus Erythematosis and what % of patients show this sign?

A

the BUTTERFLY rash and 50-80% show it

36
Q

What form of lupus has the condition that lesions are confined to skin?

A

Discoid LE

37
Q

Discoud LE: ___% have ORAL lesions: erythematous plaques or erosions with WHAT COLOR striations??

A

25%…white (like Lichen Planus)

38
Q

Systemic LE is chronic and progressive, can be LIFE-THREATENING and affect multiple organs including _____, ______, and ______

A

CNS, Heart, Kidney

39
Q

Which form of lupus has periods of remission and disease inactivity?

A

Systemic LE

40
Q

Lab tests for Lupus Erythematosus include ANA (_________) & antibodies to the patient’s own DNA

A

antinuclear antibodies

41
Q

________, anti-malarial drugs (__________), and other immunosuppressive medications are used in systemic LE

A

Corticosteroids, anti-malarial drugs (hydroxychloroquine),

42
Q

_______ are given for symptomatic treatment of SLE and _______ drugs for more SEVERE conditions

A

NSAIDS…..Antimalarial

43
Q

What is a RARE immune mediated DEPOSITION of collagen in skin and other tissues?

A

Scleroderma (systemic sclerosis)

44
Q

Systemic sclerosis / scleroderma is usualy 3:1 favoring WHICH sex?

A

women

45
Q

Which condition is associated with Raynaud’s phenomenon?

A

Systemic Sclerosis/Scleroderma

46
Q

_______ phenomenon: vasoconstrictive event in extremities triggered by stress, cold.

A

RAY-naud’s

47
Q

Raynaud’s phenomenon: vaso________ event in extremities triggered by ______, ____.

A

constrictive…stress, cold

48
Q

What is the disease when a scleroderma causes the skin to be diffuse, hard, and taut?

A

“Hide bound disease”

49
Q

Oral manifestations of Scleroderma: WTF is _______??? its found in 70%, dysphagia, ± xerostomia

A

Microstomia

50
Q

Oral manifestations of Scleroderma: diffuse ________ of PDL

A

WIDENING (the collagen is GROWING)

51
Q

DANG-Oral manifestations of Scleroderma: resorption of _____ or ______ or _______

A

RAMUS or CONDYLE or CORONOID

52
Q

SCLERODERMA affects other _______ and can lead to _______

A

organ…organ failure

53
Q

Diagnosis of Scelroderma: Clinical features and ______ 70 antibodies (_________ 1)

A

Anti-Scl (Topoisomerase 1)

54
Q

What are the two meds used to treat scleroderma?

A

D-Penicillamine and Ca Channel Blockers

55
Q

What does the prognosis of Scelroderma depend on??

A

depends on organ involvement

56
Q

Graft Vs Host Disease (GVHD) is an immune reaction following WHAT TYPE of bone marrow transplantation.

A

ALLOGENIC (from another donor)

57
Q

How much time divides chronic vs acute GVHD?

A

1st 100 days = acute….after that CHRONIC

58
Q

In GVHD the oral lesions appear ________ and PAINFUL

A

lichenoid

59
Q

What are the two types of drugs used to treat GVHD?

A

immunosuppresive meds and corticosteroids

60
Q

What is the patient at risk for when going through GVHD?

A

dysplasia and Oral Cancer

ORAL PATHOLOGY! (40 decks)

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