Exam 4: The Blood Flashcards
A fluid connective tissue consisting of blood cells and platelets.
Blood
Blood contains
Dissolved protein fibers in watery ground substance
Red blood cells transport what
Oxygen and carbon dioxide
White blood cell function
Fight off infections
Platelets and dissolved proteins help with
Clotting
Blood makes up what percent of body mass
8
How many liters of blood are produced each day in women and men?
Women= 4-5
Male=5-6
Blood has what components when separated by centrifuge?
Plasma, Buffy coat, and erythrocytes
Plasma makes up
55% of whole blood
What is in plasma
Water, proteins, and other solutes such as electrolytes and nutrients
The Buffy coat makes up
Less than 1% of whole blood
The Buffy coat is made up of
Platelets and leukocytes (WBC)
Erythrocytes make up
45% of whole blood
Red blood cells are also called
Erythrocytes
What is the most dense and least dense component in blood when separated by centrifuge
Least dense is plasma, most dense is erythrocytes
Percentage of volume of all formed elements in the blood, attributed by percentage of volume in red blood cells
Hematocrit
What is the hematocrit in males and females
Males= 42-56%, Females=38-46%
The most abundant of the plasma proteins
Albumin
Function of albumin
Retain water in blood and transport hormones
Function of fibrinogen
Help with clot formation
Function of globulins
Transport lipids
What are the main blood proteins
Albumin, fibrinogen, and globulins
Lack nuclei and organelles
Erythrocytes
Erythrocytes transport
Oxygen and carbon dioxide
Erythrocytes contain
Hemoglobin, which binds oxygen and carbon dioxide
What is an important component of hemoglobin
Iron
Average life span of erythrocytes
120 days, broken down in liver
Heme ( hemoglobin without iron) is converted into
Bilirubin, component of bile
Iron is transpired from the
Liver to bone marrow for recycling
Erythrocytes originate in
Red bone marrow
Erythrocytes function how
Anaerobically, not using oxygen they transport
There is a lot of what in the oxygen carrying hemoglobin
Cytoplasm
Main function of erythrocytes
Transport oxygen to tissues
Wrights stain is often used on
Blood smears
Heme components are
Biliverdin in bile of liver, and iron stored by ferritin in liver
Erythrocyte membranes protein and globin proteins are broken down into
Amino acids
The plasma membrane of an erythrocyte has surface antigens that
Project from the surface
Red blood cells can have what type of antigens
A, B, A and B or neither A ans B
Type A blood
Red blood cells have surface antigen A
Type B blood
Red blood cells have surface antigen B
Type AB blood
Red blood cells have A and B surface antigens
Type O blood
Red blood cells don’t have surface A or B antigen
White blood cells produce antibodies to
Surface antigens not found on an individuals red blood cells
White blood cells antibodies help to
Identify when foreign cells enter the body
A person with type A has what type of antibodies
Anti B in blood plasma
A person with type B has what type of antibodies
Anti A
A person with type AB blood has what type of antibodies
Neither anti A or anti B
A person with type O blood has what kind of antibodies
Both Anti A and anti B
If a person receives a blood transfusion that’s incompatible, antibodies…
Bind to the antigen surface and red blood cell clumps bind together (agglutination)
A person with type AB blood is a
Universal recipient
A person with type O blood is a
Universal donor
Another common surface antigen on erythrocytes is also called a
Rh antigen
Rh antigen is also called
Surface antigen D
When rh is present on the antigen, the individual is said to be
Rh positive
A rh positive person doesn’t produce
Rh antibodies
A person only produces antibodies if they are
Negative and are exposed to Rh positive blood
Leukocytes function
Initiate an immune response
Leukocytes characteristics include….
Have a nucleus, organelles, and are divided into granulocytes and agranulocytes
Wright’s stain consists of
Eosin, red, and methylene, blue.
Granulocytes have granules in their
Cytoplasm
Three granulocytes types
Neutrophils, eosinophils, and basophils
Multi-lobed nucleus, pale red and blue cytoplasmic granules
Neutrophils
Neutrophils function
Phagocytize bacteria
Bi-lobed nuclei, reddish organs granules
Eosinophils
Functions of eosinophils
Phagocytize antigen-antibody complexes and allergens; release chemical mediators to destroy parasitic worms
Bi-lobed nucleus, purplish/black cytoplasmic granules
Basophils
Function of basophils
Release histamine and heparin during allergic or inflammatory reactions
Type of antigen that produces an abnormally aggressive immune response
Allergen
Have such small granules in their cytoplasm they aren’t visible under the microscope
Agranulocytes
Three types of lymphocytes
T, B, and natural killer cells
Large spherical nucleus, thin rim of pale blue cytoplasm
Lymphocyte
Lymphocyte function
Attack pathogens, coordinate immune cell activity, and produce antibodies
Kinsey shaped nucleus, abundant pale blue cytoplasm
Monocyte
Functions of monocytes
Become macrophages, phagocytize pathogens, and engulf debris
Platelets (thrombocytes) function
Form clots in response to damage
Irregular membrane bound cellular fragments of cells called
Megakaryocytes
Megakaryocytes are found in
Red bone marrow
Parts of the Megakaryocytes…
Pinch off and enter blood stream
A low platelet count (thrombocytopenia) makes one
Prone to bleeding
Malignancy, cancer resulting in uncontrolled proliferation of white blood cells in bone marrow
Leukemia
Excessively low erythrocyte or hemoglobin concentrations
Anemia
Abnormal excess of erythrocytes in blood
Polycythemia
Defect in hemoglobin molecule in the blood, abnormal RBCs
Sickle cell disease
Abnormally low concentration of platelets in blood
Thrombocytopenia
Hemopoisesis is the production of
Blood cells, occurs in red bone mardie
Stem cells are called
Hematocytoblasts
Hematocytoblasts can produce
Myeloid or lymphoid stem cells
The lymphoid stem cells give rise to the
Three types of lymphocytes, while the myeloid stem cells produce all the other blood cells
produced by defense cells to help protect against pathogens
Immunoglobulins
How many types of white blood cells are there…
Neutrophils, monocytes, lymphocytes, eosinophils, and basophils