EXAM 3 NK Cells and gamma delta T Cells Flashcards
NK cells are derived from a common ___ precursor
lymphoid
NK cells provide the interface between what?
adaptive and innate immunity
NK cells are developmentally similar to ___ cells
T cells
NK cells have diverse ___ expression and interaction
receptor
NK cells are regulated by interactions with ___
MHC I molecules
NK cells recognize targets by their lack of ___
MHC I
can NK cells form memory cells?
yes
what determines NK cell killing?
positive and negative signal balance
describe the 3 cell states that regulate NK cell targeting
- protection - healthy cells express both stimulating and inhibitory signals
- missing-self - unhealthy cells reduce MHC I expression
- induced-self - unhealthy cells increase stress ligand expression
do all NK cells detect MHC I receptors or stress ligands?
no
in NK cell targeting, ___ signals must overcome ___ signals
- stimulating
- inhibitory
NK cells must be educated to detect a lack of ___
receptor expression
what are the important roles cytokines play in NK cell targeting?
- stimulating signal
- receptor expression
- IFNs, IL-12
do NK cells express diverse combinations of receptors or do they only have a few?
diverse combinations
what are the activating and inhibitory receptors on NK cells?
- activating - NKG2D and CD16 (Fc receptor)
- inhibitory - NKG2A and KIR family