Exam 2 Slide show Muscle Tissue (Pt3) Flashcards
What molecule spans half a sarcomere, from a Z disc to an M line, and attaches thick filaments to Z discs and M lines
Titin
What binds to titin and holds thick filaments in position from side to side, and FORMS THE M LINE in so doing
Myomesin
What links the thin filaments of the sarcomeres to integral membrane proteins in the sarcolemma, thereby transmitting the tension generated by the sarcomeres through the connective tissues of the muscle to the tendons?
Dystrophin
What attaches the sarcolemma to the basement membrane?
Sarcolemmal proteins
What refers to a group of inherited muscle-destroying diseases causing progressive skeletal muscle fiber degeneration?
Muscular Dystrophy
What is the most common form of muscular dystrophy?
Duchenne muscular dystrophy (DMD)
What protein is mutated in DMD and causes the sarcolemma to tear easily?
Dystrophin
Each muscle fiber has how many neuromuscular junctions?
One
Where is a muscle action potential generated?
The neuromuscular junction
What is a nueromusclar junction (NMJ)?
The synapse between a somatic motor neuron and a skeletal muscle fiber
What part of the neuron contains synaptic vesicles filled with acetylcholine (ACh), which carries the impulse across the synaptic cleft?
Synaptic end bulbs
What comprises the muscle fiber part of the NMJ?
The motor end plate
Where are the ACh receptors located?
The junctional folds?
What are junctional folds?
deep grooves in the motor end plate
The Binding of how many molecules of ACh opens an ion channel in the ACh receptor allowing cations, most importantly Na+, to flow across the membrane?
Two
