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Med310A > Endocrinology Of Growth > Flashcards

Endocrinology Of Growth Flashcards

1
Q

__________- specialized endothelium with tight junctions to strictly control environmental exposure and protect the brain

A

BBB

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2
Q

The hormonal output of the anterior pituitary represents a _____ feedback loop

A

Negative

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3
Q

The secretion of all anterior pituitary hormones are controlled by _____ hormones

A

Hypothalamic

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4
Q

The special portal system is a vascular network called the ___________portal system

A

Hypothalamic hypophyseal

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5
Q

Hypophysis is another word for ___

A

Pituitary

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6
Q

_____ releasing hormones stimulate release of specific hormones from the cells of the anterior pituitary that express the releasing hormone receptor

A

Hypothalamic

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7
Q

Hormone 1 of the feedback loop is secreted from the ____and travels to the _____

A

Hypothalamus
Anterior pituitary

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8
Q

Hormone 2 of the feedback loop is secreted from the _____ and travels to the target_______

A

Anterior pituitary
Target endocrine gland

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9
Q

Hormone 3 is secreted from the _____ and travels to the target ___

A

Endocrine gland
Tissue

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10
Q

If hormone 1 is deficient What happens to:
- hormone 2 and 3
-negative feedback

A

Will be low
Reduced

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11
Q

If hormone 1 level rises then hormone 2 and 3 will__

A

Rise

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12
Q

Hypothalamic releasing hormones, their anterior pituitary hormones and their target cell hormones exhibit _____ rhythms

A

Circadian

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13
Q

Describe the circadian rhythm of secretion

A

1 peak very 24 h
Sleep/wake cycle

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14
Q

Do anterior pituitary hormones peak at same or different times?

A

Different

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15
Q

Hormone 2 of feedback loop:
What are the three families of anterior pituitary hormones ?

A
  1. Glycoprotein
  2. POMC
  3. GH/Prolactin
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16
Q

_____ family
- hydrophilic
-small glycosylated proteins
-produced & stored in anterior pituitary cells
1. FSH
2.LH
3. Gonadotropins
4. TSH

A

Glycoprotein

17
Q

Collectively, FSH and LH are called _____

A

Gonadotropins

18
Q

FSH & LH act on _______ target cells

A

Gonadal

19
Q

TSH acts on ____ gland target cells to stimulate secretion of this glands hormone

A

Thyroid

20
Q

CRH from the hypothalamus stimulates production of ______ by corticosterone’s of the anterior pituitary

A

POMC

21
Q

_____ from the hypothalamus stimulates production of POMC by corticotropes of the anterior pituitary

A

CRH

22
Q

In corticotropes, the large POMC glycoprotein pro-hormone is cleaved to produce:
1.
2.
3.

A

ACTH
Beta-endorphin
Gamma-lipotropin

23
Q

What hormone targets cells in adrenal gland Cortex and controls secretion of adrenal cortical hormones such as aldosterone, cortisol and androgens

A

ACTH

24
Q

____ hormone stimulates milk production in lactating women as well as fertility regulation in men and women and maintenance of immune system

A

Prolactin

25
Q

____ hormone regulates metabolism and growth

A

GH

26
Q

______ hormone is stimulated by stress, exercise, hypoglycaemia, amino acids, first 2 hours of sleep

A

GH

27
Q

______ is abnormally large growth due to an excess of growth hormone during childbirth before the bone growth plates have closed

A

Gigantism

28
Q

______ is when height is unchanged but mature bones become thicker(hands, face, feet) exhibited coarseness of features

A

Acromegaly

29
Q

GHRH, GH, or IGF-1 deficiency is called ______ dwarfism

A

Pituitary

30
Q

Unresponsive GH receptors is causes ____ dwarfism

A

Laron

31
Q

______ is a cause of dwarfism and is when thyroid hormones are permissive for action of GH

A

Hypothyroidism

32
Q

Genes defect for cartilage FGF(Fibroblast growth factor) receptor impairs bone ossification which causes _____ dwarfism

A

Achondroplasia

Med310A (29 decks)

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