Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Cardiovascular > Dyslipidaemia Drugs > Flashcards

Dyslipidaemia Drugs Flashcards

1
Q

What causes secondary dyslipidaemia?

A

type 2 diabetes, hypothyroidism, alcoholism, liver disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the contraindications to ezetimibe?

A

breast feeding

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are statins used for?

A

first line to reduce LDL, also reduce total cholesterol and triglycerides, modestly increases HDL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the adverse effects of statins?

A

rare - incidence increased if combined with a fibrate, myositis - muscle inflammation and degeneration, rhabdomyolysis - destruction of striated muscle cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the adverse effect of bile acid binding resins?

A

GI irritation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Give examples of bile acid binding resins

A

colestyramine, colestipol, colsevelam

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How is ezetimibe administered?

A

orally

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Give examples of lipid lowering drugs?

A

statins, fibrates

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

How are statins administered?

A

orally at night

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the mechanism of action of fibrates?

A

agonists of nuclear receptors that enhance transcription of several genes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Give examples of fibrates

A

bezafibrate, gemfibrozil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the adverse effects of fibrates?

A

incidence greater than for statins, myositis - muscle tissue inflammation and degeneration, rhabdomyolysis - destruction of striated muscle cells, GI symptoms, pruritus - severe itching of the skin, rash

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Give examples of statins

A

simvastatin, atorvastatin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the mechanism of action of bile acid binding resins?

A

more cholesterol converted to bile salts, decreased absorption of triglycerides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What causes primary dyslipidaemia?

A

diet and genetic factors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are the adverse effects of ezetimibe?

A

diarrhoea, abdominal pain, headache

17
Q

Give examples of drugs that inhibit cholesterol absorption

A

bile acid binding resins, ezetimibe

18
Q

What do low density lipoproteins cause?

A

atherosclerosis

19
Q

What are the other benefits of statins?

A

decreased inflammation, reversal of endothelial dysfunction, decreased thrombosis, stabilisation of atherosclerotic plaques

20
Q

What is the role of high density lipoprotein?

A

removes cholesterol from cells - transports it to the liver where it is broken down

21
Q

What are fibrates used for?

A

first line to decrease triglycerides, modest decrease in LDL, modest increase in HDL

22
Q

How are bile acid binding resins administered?

A

orally

23
Q

What is dyslipidaemia?

A

high levels of LDL and/or low levels of HDL, increases risk of CHD and stroke

24
Q

What is the mechanism of action of statins?

A

competitive inhibitors of enzyme responsible for cholesterol synthesis in hepatocytes

25
Q

What is the mechanism of action of ezetimibe?

A

reduces absorption of cholesterol, decreases LDL

Cardiovascular (37 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions