Connective Tissue Flashcards
Functions of connective tissue?
Barrier to infection, support, store energy, tissue repair
Main components of ECM?
GAGs, proteoglycans, glycoproteins, collagen, reticular fibers, elastin
GAG structure and function?
Long repeating disaccharides, attract water and cations. Gel like
Proteoglycans structure?
GAGs linked to protein by tetrasaccharide. For lubrication and structure
Glycoprotein structure and function?
Mostly protein, many docking sites. Allows for organization and vascular development
What type of collagen is reticular fiber made of?
Type 3
How can edema happen?
Decreased venous return, increased permeability, starvation
Steps in synthesis of collagen?
Preprocollagen cleaved to Procollagen. Prolines and lysines hydroxlated and then glycosylated. Assembled into triple helix, then registration sequences cleaved.
How are collagen fibrils formed?
Cross linking by copper dependent lysyl oxidase. Fibrils then can form fibers
Where is type one collagen found? 2? 3?
Bones, teeth. Cartilage. Smooth muscle
Elastic fiber formation and purpose?
Elastin and microfibrils (made by fibrillin 1) attached by desmosin. Fibers or sheets
Osteogenesis imperfects symptoms and cause?
Inherited, abnormal triple collagen helix. Systemic. Error in alpha1/2 genes
Systemic sclerosis cause and symptoms?
Excessive collagen, hardened around organs. Problem with turnover
Ehlers Danlos symptoms and cause?
Joint hyper mobility, skin elasticity. Defect in collagen processing.
Marfan syndrome cause?
Defect in fibrillin 1 gene
