Cartilage

Question 1

Chondrogenic cell location and purpose?

Answer 1

In perichondrium, spindle shaped and give rise to chondroblasts

Question 2

Chondroblast function?

Answer 2

Produce most of cartilage matrix

Question 3

Chondrocyte purpose?

Answer 3

Formed of chondroblast, maintain matrix. In lacunae

Question 4

What stimulates and inhibits cartilage formation?

Answer 4

Stimulated by IGf1, thyroid hormone, and testosterone. Inhibited by cortisone and estradiol

Question 5

What is cartilage matrix made of?

Answer 5

Type two collagen, and aggrecan molecules. Water and chondronectin( binds cyte to collagen)

Question 6

Aggrecans are high in GAGs to do what?

Answer 6

Attract water for slipperyness and cushion

Question 7

What are the two types of cartilage formation and how do they work?

Answer 7

Interstitial-division of blasts and cytes in cartilage

Appositional-division of chondrogenic cells at periphery

Question 8

Difference between territorial matrix and inter territorial?

Answer 8

Territorial stains darker, high in chondroitin sulfate, at periphery. Inter is bulk of matrix

Question 9

Three types of cartilage?

Answer 9

Hyaline- cushions articulate surfaces, bone templates.
Elastic cartilage-flexible, high in elastin
Fibrocartilage-looks like dense CT, no perichondrium. High collagen

Question 10

Do chondrocytes use glucose aerobically?

Answer 10

No