Bone Flashcards
Bone purpose?
Support and storage of calcium and phosphate
Osteoblast function?
Make most of matrix, fuse monocytes into osteoclasts
Osteocyte function?
Have long processes in channels called canaliculi to transport soluble calcium to blood
Osteoclast function?
Liberate calcium and blood. Bind to osteopontin to make zone for destruction. Formation stimulated by PtH. Remodel bone
Endochondral bone formation steps?
Cartilage plan. Perichondrium turns to periosteum, forming collar. Calcify lacunae, chondrocytes die. Osteoclasts cut channel, bringing stem cells to produce matrix
Intramembranous bone formation?
Mesenchyme forms osteoblasts. Make spicules, weaving together into woven bone. Spaces around capillaries fill with bone
Epiphyseal plate zones near to far?
Ossification, calcification, hypertrophy, proliferation, resting.
Calcitonin vs PTH?
Calcitonin lowers serum
Calcium, PtH raises
Testosterone vs estrogen in bone?
Testosterone stimulates osteoblasts and epiphyseal plate growth. Estrogen prevents bone loss and inhibits plate at puberty
Lamellae?
Layers of bone around canal
Haversian system?
Sleeves of bone around a nutrient canal
Bone cell layers?
Out to in- periosteum (collagen, progenitor, blasts), matrix(cytes and bones), inner is endosteum.
What is spongy bone?
Trabecullar?
Alkaline phosphatase?
Helps take up of phosphate for bone making. High in bone cancer
Where do large macromolecules go in bone?
around the outside of cells in canaliculi
