Blood Development

Question 1

When is the yolk sac phase?

Answer 1

3 weeks to 3 months. Blood islets. Nucleated

Question 2

Hepatic phase of blood making?

Answer 2

Second trimester, anucleated

Question 3

Bone marrow phase of blood formation?

Answer 3

4 th month on. Anucleated

Question 4

What two lineages do hematopoietic stem cells make?

Answer 4

Myeloid and lymphoid. Can be used in marrow grafting.

Question 5

How do RBCs leave marrow?

Answer 5

Via endothelial sinusoids in bone

Question 6

What factors do hematopoietic stem cells need to function?

Answer 6

ScF, CXCLI2, G-CSF, made by stromal cells

Question 7

What is erythroblastic island?

Answer 7

RBC types around macrophage, which eats spit out nucleus

Question 8

Steps of RBC making?

Answer 8

Basilophilic( giant nucleus, very blue, much ribosomes), polychromatophilic( gray blue clumpy), orthochromatophilic( dark nucleus, tan cyto), reticulocyte( organelles no nucleus), RBC

Question 9

Steps in granulocyte maturation?

Answer 9

Promyelocyte(nucleus same color as granules), myelocyte(new granule color), metamyelocyte(dented nucleus), band, mature.

Question 10

Megakaryocte look?

Answer 10

Large, polyploid

Question 11

Do most cells mature in marrow?

Answer 11

No, mostly periphery