chapter seven Flashcards
function of plasma membrane
- protects cell from external environment
- mediates cellular transport
- transmits cellular signals
selective permeability
controlled flow of substances in/out of the cell
- some cross more easily than others
staple ingredients of membranes
lipids and proteins
phospholipid bilayers
hydrophilic head, hydrophobic tails
- 2 phospholipids held together by hydrophobic interactions
amphipathic molecules
both polar and nonpolar
fluid mosaic model
membrane is a mosaic of protein molecules bobbing in a fluid layer of phospholipids
evidence for fluid nature of membrane
- cell fusion (hybrid cell)
- movement of proteins
cell fusion (hybrid cell)
mouse and human cells fused, proteins on membranes mixed laterally
movement of proteins
- shifts laterally (sideways)
- slower than lipid movement because larger
- many proteins immobile by attachment to cytoskeleton and ECM
flip flops
lipid can switch from 1 phospholipid layer to another
- need flippers/floppers
- phospholipids can’t do on own
unsaturated hydrocarbons
double bonds (kinked tails) prevent packing and enhance fluidity
saturated hydrocarbons
hydrocarbon tails pack together and decrease fluidity
cholesterol
effects membrane fluidity
- fluidity buffer - resists change
- high temp - membrane less fluid by restraining phospholipid movement
- lowers temp required for membrane to solidify
2 types of membrane proteins
integral and peripheral
integral proteins
penetrate hydrophobic interior of lipid bilayer
- includes transmembrane proteins (span membrane)
- hydrophobic regions consist of 1+ stretches of nonpolar amino acids coiled in a helices
peripheral proteins
not embedded in lipid bilayer, loosely bound to surface
ECM
non-cellular componente of tissues and organs
- contains macromolecules
functions of membrane proteins
- transport
- enzymatic activity
- signal transduction
- cell-cell recognition
- intracellular joining
- attachment to cytoskeleton/ECM
what does cell-cell recognition require?
one protein to be a glycoprotein
importance of cell recognition
sorting of cells/tissues in embryo, rejection of foreign cells
molecule structure of cell recognition
cells bind to molecules (often containing carbohydrates) on ec surface
glycolipids
carbohydrates bonded covalently to lipids
glycoproteins
carbohydrates covalently bonded to proteins
what substances pass by “free” diffusion (passive)
- gases
- small greasy molecules (steroids, non polar substances, hormones)
passive transport
diffusion that requires no energy and travels down the concentration gradient
- gradient represents potential energy
diffusion
movement of particles of any substance so they spread out into available space