chapter nineteen Flashcards
viruses
tiny, infectious particles that contain genes packaged in a protein coat
what are viruses also known as?
obligate intracellular parasites
- can replicated only within host cell
how were viruses discovered?
TMV (tobacco mosaic virus) in 1930s
- filtrable agents - small enough to pass through filter
- non-cellular
- crystallizable
structure of virus
nucleic acid genome, capsid, sometimes envelope
nucleic acid genome of virus
DNA or RNA, double stranded or single stranded
- 4 to hundreds of genes
capsid
protein coat or shell enclosing viral genome
- built from subunits (capsomeres)
envelope
derived from host plasma membrane, contains lots of glycoprotein spikes to bind to receptors on host
naked virus
doesn’t have envelope, just genome and capsid
for which cells does the host plasma membrane not form the virus envelope?
fungal and plant cells
shapes examples
- spiral - TMV
- polyhedron - adenovirus (common cold)
- complex - bacteriophages (lunar lander)
host ranges
limited number of host species that each particular virus can infect
- hosts identified by “handshake” between receptor molecules and glycoproteins
broad host examples
West Nile virus, influenza, equine encephalitis
- mosquitos, horses, birds, humans
restricted host examples
HIV, smallpox, measles
- humans, particular tissues
overview of virus entering host
- virus enters cell and releases viral DNA/capsid proteins
- host enzymes replicate viral genome
- host enzymes transcribe viral genome, make virus parts
lytic cycle
virulent, kills host 20-40 min
1. attachment - surface proteins
2. penetration - entry of phage DNA, degradation of host DNA (hydrolyzed)
3. biosynthesis - using host’s cellular machinery to make viral genomes/proteins
4. assembly/maturation of new viruses
5. lysis - lysozymes rupture wall, 100-200 particles released