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Mental Health > Chapter 3: Neurobiology and Pharmacotherapy > Flashcards

Chapter 3: Neurobiology and Pharmacotherapy Flashcards

1
Q

what leads to behaviors

A

feels
thinks
neurobiological imbalances

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2
Q

what does the biopsychoscial hypothesis say

A

biological
psychological (traits, coping)
environmental factors

lead to mental illness

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3
Q

dopamine
increased

A

schizophrenia

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4
Q

dopamine
decreased

A

ADHD
parkinsons

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5
Q

norepinephrine
decreased

A

depression

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6
Q

norepi
increase

A

mania
anxiety
schizophrenia

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7
Q

serotonin
decrease

A

depression

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8
Q

serotonin

A

anxiety

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9
Q

GABA
decrease

A

anxiety
schizophrenia
mania
huntingtons

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10
Q

GABA
increase

A

reduces anxiety

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11
Q

glutamate
decrease

A

psychosis

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12
Q

glutamate
increase

A

prolonged is neurotoxic and causes neurodegnerntation in alzhimers

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13
Q

cholinergics
decrease

A

alshiemers
huntigntons
parkinsons

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14
Q

cholinergic
increase

A

depression

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15
Q

pharmacodynamics

A

what do drugs do

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16
Q

pharmacokinetics

A

actions on the body

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17
Q

ADME

A

absorption
distribution
metabolism
excretion

18
Q

benzodiazepine

A

promote GABA
addictive
sedative
hypnotic

antiaxiety
also insomnia and withdrawl

19
Q

z drugs

A

sedative effects with out anxiety, anticonvulsant, or muscle relaxants

quick onset
short half life

20
Q

buspirone

A

relieves anxiety without sedation
no addition
not CNS depresant

21
Q

TCAs

A

sedation
lethal overdose
anti slud
takes long time to work
norepinephrine/ norepinephrine and serotonin

ortho hypo
confusion
fatal arrhythmia
titrate down to prevent HA
weight changes

bipolar= hypomania or mania

22
Q

MAOI

A

enzyme that destroys monoamines
avoid tyramine or hypertensive cirsis
weight gain
sexual dysfunction
photosensitivity
urine retention
decrease seizure threshold
increase suicide
urine retention

23
Q

tyramine foods

A

age cheese
cured meats
smoked meats
pickled
fermented
soybean
asian cuisine sauces (soy, shrimp, fish, miso)
snow peas/fava beans
beer, wine, liquor
dried/overripe fruit
meat tenderizer
old spoiled foods
chocolate

24
Q

what can occur with MAOI and SSRI

A

serotonin syndrome

25
Q

serotonin syndrome

A

tachycardia
sweating
fever/hyperthermia *
shivering
tremor
muscle rigiidty
restlessness

26
Q

SSRI

A

use beside depression
anxiety
OCD
bulimia

affect serotinin

Anti slud
N/H
menstruation pain
sexual dysfunction
weight gain/loss
take med in AM
4 weeks to work

27
Q

SNRI

A

affect serotonin and norepinephrine

increase HR and BP

28
Q

NaSSA

A

norepinephrine and serotonin
and histamine

sedation and weight gain
agranulocytosis
safe in overdose
increase lipids
decrease sexual dysfunction
also works in anxiety and insomnia
decrease sexual dysfunction

good for elderly *
- sedation and weight gain might be beneficial

29
Q

NDRI

A

norepinephrine and dopamine

smoking cessation
no sexual dysfunction*
must taper or seizure risk
may cause appetite supression

30
Q

SARI

A

serotonin antagonist and reuptake inhib

31
Q

SARI
trazadone

A

priapism and sedating

32
Q

Serotonin modulator and stimulator

A

atypical so works for major depression

improve cognition deficits in elderly
hyponatremia and hypomania

33
Q

lithium

A

depression and mania (bipolar)
narrow therapeutic index (.8-1.4)
toxic (1.5)

34
Q

what could cause a pt to get lithium toxiticyt

A

dehydration
NSAIDS
diuretics
BP meds

35
Q

toxic effects of lithium acute

A

tremor
ataxia
confusuon
convulsions
N/V/D
stomach pains
seizures
coma
kidney failure
nystagmus

36
Q

side effects of mood stabilizers

A

weight gain
somnolence
agranulocytosis
thrombocytopenia
hepatitis
Steven johnson

37
Q

chronic lithium toxicity

A

tremor
slurred speech
increase reflex

38
Q

suspisois of Li tox

A

blood levels
BUN
creatinine

39
Q

antipsychotics
first gen

A

dopamine
acetylcholine, norepinephrine, histamine
typical

weight gain
sedation
increase prolactin
anti slud
increase EPS
positive symptoms

40
Q

antipsychotics
2nd gen

A

dop and seroatinin
schizophrenia
atypical
decrease EPS
increase metabolic syndrome
- insulin resistance
positive and negative

Mental Health (81 decks)

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