Chapter 1 Inflammatory Response

Question 1

Cells that produce TNFa

Answer 1

Major source activated M1 macrophages

Question 2

proinflammatory cytokines

Answer 2

TNF-a
IL-1a
IL-1B
IL-6
Chemokines (chemotactic cytokines)

Question 3

anti-inflammatory cytokines

Answer 3

IL-4
IL-10
IL-13

Question 4

What is TNF-alpha

Answer 4

membrane bound surface protein cleaved by metalloproteases that is released in soluble form and a pro inflammatory cytokine

Question 5

What about TNF- A in humans

Answer 5

Commercially available anti-TNF monoclonal antibodies and recombinant TNF soluble receptors have proven efficacious in human patients with Crohn’s disease and rheumatoid arthritis

Question 6

What are the effects of inhibiting TNF-a

Answer 6

Recrudescense of pulmonary mycobacterial infections and infectious complications after ortho surgery