Chap 18 Endocrine System Flashcards
Introduction Endocrine System
- Glands release hormones.
- Hormones regulate the many and varied functions of an organism.
- Hormones bind to receptors.
- Receptors are recognition sites in the various target tissues on which hormones act.
ENDOCRINE glands—
EXOCRINE glands—
- ENDOCRINE glands—
Secrete their hormones directly into the bloodstream - EXOCRINE glands—
Send chemical substances (tears, sweat, milk, saliva) via ducts to the outside of the body
Endocrine Glands
- Thyroid gland
- Parathyroid glands (four glands)
- Adrenal glands (one pair)
- Pancreas (islets of Langerhans)
- Pituitary gland
- Ovaries (one pair)
- Testes (one pair)
- Pineal gland
- Thymus gland
- Thyroid Function
- There are two hormones:
+ Thyroxine or tetraiodothyronine (T4)
+ Triiodothyronine (T3). - Thyroid hormones aid cells in their uptake of oxygen and regulate metabolic rate.
- Calcitonin: stimulates calcium to leave the blood and enter the bone.
Parathyroid Function
Parathyroid hormone (PTH):
Parathyroid hormone (PTH): causes calcium to mobilize from bones into the bloodstream
- Adrenal Glands: Location and Structure
Each gland has two parts
- An outer portion, the adrenal cortex
+ Secretes corticosteriods or steriods, chemicals derived from cholesterol - An inner portion, adrenal medulla
+ Secretes catecholamines
chemicals derived from amino acids
- Function: Adrenal Cortex Secretes
- Glucocorticoids: influence metabolism of sugars, fats, and proteins (cortisol) and are anti-inflammatory (cortisone). Influences—SUGAR
- Mineralocorticoids: regulate electrolytes
Aldosterone: reabsorption of sodium/excretion of potassium. Influences—SALT - Gonadocorticoids: androgens and estrogens. Influences—SEX
Function: Adrenal Medulla Secretes
Two types of catecholamine hormones
- Epinephrine (adrenaline): increases heart rate and blood pressure, dilates bronchial tubes, releases glucose from storage
- Norepinephrine (noradrenaline): constricts vessels to raise blood pressure
- Both are sympathomimetic agents
PANCREAS
- Located near and partially behind the stomach
- Exocrine and endocrine organ
- Pancreas Function
Endocrine function
- Islets of Langerhans produce:
+ Insulin: promotes movement of glucose into cells and promotes storage as glycogen
+ Glucagon: promotes movement of glucose into the blood by breaking down glycogen stored in liver cells
Pituitary Gland
- Pea-sized gland in depression of skull (sella turcica) also called the hypophysis
+ Anterior lobe (adenohypophysis)
+ Posterior lobe (neurohypophysis) - Hypothalamus controls secretions of the pituitary via releasing factors (hormones)
- Pituitary Function
a. Anterior pituitary:
- Growth hormone (GH) or somatotropin (STH)
- Thyroid-stimulating hormone (TSH; thyrotropin)
- Adrenocorticotropic hormone (ACTH)
- Gonadotropic hormones (FSH, LH)
- Prolactin (PRL)
b. Posterior pituitary: stores and releases hormones synthesized in the hypothalamus
- Antidiuretic hormone (ADH; vasopressin)
- Oxytocin (OT)
Ovaries and Testes: Hormones and Actions
Ovaries secret:
- Estrogen (Estradiol): female sexual characteristics - Progesterone: mantains pregnancy
Testes secret:
- Androgen (Testosterone) : male sexual characteristics
Male (Testest)
Female (Ovaries)
Testes
- Hormone: testosterone
+ Maintains germ cell formation and secondary sexual characteristics
Ovaries
- Hormones: estrogen and progesterone
+ Maintains menstrual cycle, release of ovum, secondary sexual characteristics, preparation of uterus for pregnancy
adrenal cortex
Outer section of each adrenal gland; secretes cortisol, aldosterone, and sex hormones
adrenal medulla
Inner section of each adrenal gland; secretes epinephrine and norepinephrine
ovaries
Located in the lower abdomen of female; responsible for egg production and estrogen and progesterone secretion
pancreas
Located behind the stomach
parathyroid glands
Four small glands on the posterior of the thyroid gland
pituitary gland (hypophysis)
Located at the base of brain in the sella turcica
testes
Two glands enclosed in the scrotal sac of a male; responsible for sperm production and testosterone secretion
thyroid gland
Located in the neck on either side of the trachea; secretes thyroxine, triiodothyronine, and calcitonin
adrenaline (epinephrine)
Secreted by the adrenal medulla; increases heart rate and blood pressure
Adrenocortico-tropic hormone (ACTH)
Secreted by the anterior lobe of the pituitary gland; stimulates adrenal cortex
aldosterone
Secreted by the adrenal cortex; increases salt reabsorption
androgen
Male hormone secreted by the testes and adrenal cortex (to a lesser extent)
antidiuretic hormone (ADH)
Secreted by the posterior lobe of the pituitary gland; increases reabsorption of water by kidney
calcitonin
Secreted by the thyroid gland; decreases blood calcium levels
cortisol
Secreted by the adrenal cortex; increases blood sugar
epinephrine (adrenaline)
Secreted by the adrenal medulla; increases heart rate and blood pressure
estradiol
estrogen
follicle-stimulating hormone (FSH)
glucagons
estradiol: Estrogen secreted by the ovaries
estrogen: Female hormone secreted by the ovaries and adrenal cortex (to lesser extent)
follicle-stimulating hormone (FSH): Secreted by the anterior lobe of the pituitary gland; stimulates hormone secretion and egg production by ovaries and sperm production by testes
glucagons: Secreted by alpha islet cells of pancreas; increases blood sugar
growth hormone (GH); somatotropin
insulin
luteinizing hormone (LH)
growth hormone (GH); somatotropin: Secreted by the anterior lobe of the pituitary gland; stimulates growth of bones and soft tissues
insulin: Secreted by beta islet cells of pancreas; helps glucose pass into cells and promotes conversion of glucose to glycogen
luteinizing hormone (LH): Secreted by the anterior lobe of pituitary gland; stimulates ovulation in females and testosterone secretion in males
norepinephrine
oxytocin (OT)
parathormone (PTH)
progesterone
norepinephrine: Secreted by the adrenal medulla; increases heart rate and blood pressure
oxytocin (OT): Secreted by the posterior lobe of the pituitary gland; stimulates contraction of uterus during labor and childbirth
parathormone (PTH): Secreted by parathyroid glands; increases blood calcium
progesterone: Secreted by the ovaries; prepares the uterus for pregnancy
prolactin (PRL)
somatotropin (STH)
testosterone
thyroid-stimulating hormone (TSH); thyrotropin
prolactin (PRL): Secreted by the anterior lobe of the pituitary gland; promotes milk secretion
somatotropin (STH): Secreted by the anterior lobe of the pituitary gland; growth hormone
testosterone: Male hormone secreted by the testes
thyroid-stimulating hormone (TSH); thyrotropin: Secreted by the anterior lobe of the pituitary gland; promotes thyroid function
thyroxine (T4)
triiodothyronine (T3)
vasopressin
thyroxine (T4): Secreted by the thyroid gland; increases cell metabolism
triiodothyronine (T3): Secreted by the thyroid gland; increases cell metabolism
vasopressin: Secreted by the posterior lobe of the pituitary gland; antidiuretic hormone (ADH); raises water reabsorption and raises blood pressure
catecholamines
corticosteroids
electrolyte
glucocorticoid
catecholamines: Hormones derived from an amino acid and secreted by the adrenal medulla
corticosteroids: Hormones produced by the adrenal cortex
electrolyte: Mineral salt found in blood and tissues
glucocorticoid: Steroid hormone secreted by the adrenal cortex; regulates glucose, fat, and protein metabolism
homeostasis
hormone
hypothalamus
mineralocorticoid
homeostasis: Tendency of an organism to maintain a constant internal environment
hormone: Substance secreted by an endocrine gland to influence structure or function of an organ or gland
hypothalamus: Region of the brain lying below the thalamus and above the pituitary gland
mineralocorticoid: Steroid hormone secreted by the adrenal cortex to regulate mineral salts and water balance in the body
receptor
sella turcica
sex hormones
receptor: Cellular or nuclear protein that binds to a hormone so that a response can be elicited
sella turcica: Cavity in the skull that contains the pituitary gland
sex hormones: Steroids produced by the adrenal cortex to influence male and female sexual characteristics
steroid
Sympatho-mimetic
target tissue
steroid : Complex substance related to fats and of which many hormones are made
Sympatho-mimetic: Pertaining to mimicking or copying the effect of the sympathetic nervous system
target tissue: Cells of an organ that are affected or stimulated by specific hormones
The outer section of each adrenal gland is the:
adrenal medulla
adrenal cortex
adrenaline
adrenocorticotropic hormone
B: adrenal cortex.
Secreted by the anterior lobe of the pituitary gland; stimulates ovulation in females and testosterone secretion in males: luteinizing hormone (LH) estrodoil oxytocin prolactin
A: luteinizing hormone (LH).
- aden/o
gland
- adrenal/o
adrenal glands
- gonad/o
sex glands (ovaries, testes)
- pancreat/o
pancreas
- parathyroid/o
parathyroid gland
- pituitar/o
pituitary gland; hypophysis
- thyr/o
thyroid gland
- thyroid/o
thyroid gland
- andr/o
male
- calc/o, calici/o
calcium
- cortic/o
cortex, outer region
- crin/o
secrete
- dips/o
thirst
- estr/o
female
- gluc/o, glyc/o
sugar
- home/o
sameness
- hormon/o
hormone
- kal/I
potassium (an electrolyte)
- lact/o
milk
- myx/o
mucus
- natr/o
sodium (an electrolyte)
- phys/o
growing
- somat/o
body
- ster/o
solid structure
- toc/o
childbirth
- toxic/o
position
- ur/o
urine
- -agon
assemble, gather together
- -emia
blood condition
- -in, -ine
a substance
- -tropin
stimulating the function of
- -uria
urine condition
- eu-
good, normal
- hyper-
excessive, above
- hypo-
deficient, below
- oxy-
rapid, sharp, acid
- pan-
all
- poly-
much or increased
- tetra-
four
- tri
three
Which term means surgical excision of the adrenal gland (specifically)?
Adenectomy
Adrenopathy
Adrenalectomy
Pancreatectomy
C: adrenalectomy.
Which term means a blood condition of too little potassium?
Hyperkalemia
Hypocalcemia
Hypercalciuria
Hypokalemia
D: hypokalemia.
PATHOLOGY—THYROID GLAND
Goiter: Enlargement of the thyroid
- Hypersecretion
Hyperthyroidism- > Graves’disease
- Exophthalmos and proptosis
- > Graves’disease
- Hyposecretion
Hypothyroidism
-> Myxedema
-> Cretinism - Neoplasms
Thyroid carcinoma
PATHOLOGY—PARATHYROID
- Hypersecretion Hyperparathyroidism Loss of bone density Kidney stones Hypercalcemia
- Hyposecretion Hypoparathyroidism Muscle and nerve weakness Tetany Hypocalcemia
PATHOLOGY—ADRENAL CORTEX
- Hypersecretion
+ Adrenal virilism
Amenorrhea, hirsutism, acne, voice deepening
+ Cushing syndrome
Obesity, moonface, thoracic fat deposition - Hyposecretion
+ Addison disease
Deficient mineralocorticoids and glucocorticoids, hyponatremia, fatigue, weakness, weight loss, low blood pressure
PATHOLOGY—ADRENAL MEDULLA
- Hypersecretion
+ Pheochromocytoma
- Benign tumor of adrenal medulla
- Excess epinephrine and norepinephrine
- Hypertension, tachycardia, palpitations, severe headaches, sweating, flushing of the face, and muscle spasms
PATHOLOGY—PANCREAS
- Hypersecretion
+ Hyperinsulinism
Hypoglycemia, convulsions, fainting - Hyposecretion
+ Diabetes mellitus
Lack of insulin secretion or resistance of insulin in promoting sugar, starch, and fat metabolism in cells
Type 1 : childhood onset, typically; can occur in adulthood
Type 2 : adult onset, typically
Pathology Pituitary Gland: (Anterior Lobe)
- Hypersecretion
+ Acromegaly
+ Gigantism - Hyposecretion
+ Dwarfism
+ Panhypopituitarism
Pathology Pituitary Gland: (Posterior Lobe)
- Hypersecretion
+ Syndrome of inappropriate ADH (SIADH)
Excess ADH
Excess water retention - Hyposecretion
+ Diabetes insipidus
Deficient ADH
Polyuria and polydipsia
Laboratory Tests
- Fasting plasma glucose (FPG)
- > Measures circulating glucose in a patient who has fasted at least 8 hours
- Serum and urine tests
- > Measures hormones, electrolytes, glucose, etc., in blood and urine as indicators of endocrine function
- Thyroid function tests
- > Measures T3, T4, and TSH in the bloodstream
Clinical Procedures
Exophthalmometry Computed tomography (CT) scan Magnetic resonance imaging (MRI) of the head Radioactive iodine uptake (RAIU) Thyroid scan Ultrasound examination
Exophthalmometry Computed tomography (CT) scan Magnetic resonance imaging (MRI) of the head Radioactive iodine uptake (RAIU) Thyroid scan Ultrasound examination