Ch 93: Antiviral Agents I: Drugs for Non-HIV Viral Infections Flashcards
1
Q
What is the first drug of choice for most infections caused by herpes simplex virus and varicella-zoster virus?
A
Acyclovir [Zovirax]
p. 1106
2
Q
Viruses use host-cell _______ and __________ to reproduce, making it difficult to ________ viral reproduction without also _______ cells of the host.
A
enzymes; substrates; suppress; harming
p. 1122
3
Q
How does acyclovir work?
A
It suppresses viral reproduction by inhibiting viral DNA polymerase and by causing premature termination of viral DNA strand growth.
(p. 1122)
4
Q
How is acyclovir metabolized?
A
It is eliminated unchanged by the kidneys.
p. 1122
5
Q
What are the major adverse effects of ganciclovir?
A
granulocytopenia and thrombocytopenia
p. 1122
