Ch 34: Sedative-Hypnotic Drugs

Question 1

What schedule is zolpidem (Ambien) under?

Answer 1

Schedule IV

p. 378

Question 2

Zaleplon is good for helping patients ….

Answer 2

…fall asleep, but not for maintaining sleep.

p. 378

Question 3

Eszopiclone is known by the trade name…

… and is approved for treating insomnia with no…

Answer 3

…Lunesta
…limitation on how long it can be used.

(p. 378)

Question 4

Of the major drugs for insomnia, _________ is the only one not regulated as a controlled substance.

Answer 4

ramelteon

p. 379

Question 5

How does ramelteon work?

Answer 5

It binds with melatonin receptors (MT1 and MT2, but NOT MT3).

(p. 379)

Question 6

What is the only hormone that can be purchased without a prescription?

Answer 6

Melatonin

p. 379

Question 7

What are 4 indications for barbiturates?

Answer 7

daytime sedation, induction of sleep, suppression of seizures, and general anesthesia

(p. 380)

Question 8

Barbiturates with the highest lipid solubility have the…

Answer 8

…shortest duration of action.

p. 380

Question 9

Since barbiturates can directly mimic GABA, there is no ceiling to the…

Answer 9

…degree of CNS depression they can produce.

p. 380

Question 10

Generally speaking, cross-tolerance exists among all general CNS depressants (name 4 examples), but does not produce significant cross-tolerance with _______.

Answer 10

benzos, alcohol, barbiturates, and general anesthetics.
opioids.

(p. 381)