Ch 35: Management of Anxiety Disorders

Question 1

What are the 6 benzodiazepines approved for treatment of anxiety? (A-C-C-D-L-O)

Answer 1

Alprazolam (Xanax)
Chlordiazepoxide (Librium)
Clorazepate
Diazepam
Lorazepam 
Oxazepam 

(p. 389)

Question 2

What are the FDA-approved first line drugs for treatment of generalized anxiety disorder (GAD)?

Answer 2

Benzodiazepines
Buspirone
4 antidepressants: escitalopram, paroxetine
venlafaxine, duloxetine

(p. 388)

Question 3

What is buspirone and name 3 of its characteristics?

Answer 3

It’s an anxiolytic drug that differs significantly from the benzodiazepines.

1. ) it is NOT a CNS depressant
2. ) it has no abuse potential
3. ) it does not intensify the effects of CNS depressants.

(p. 389)

Question 4

Buspirone is labeled only for __________ treatment of anxiety.

Answer 4

short-term

p. 389

Question 5

Buspirone binds with high affinity to receptors for _________ and with lower affinity to receptors for ________, but does not bind to receptors for _____ or _______________.

Answer 5

serotonin
dopamine
GABA or benzodiazepines

(p. 390)

Question 6

What is agoraphobia?

Answer 6

A condition characterized by anxiety about being in places or situations where escape might be difficult or embarrassing.

(p. 390)

Question 7

Drug therapy for panic attacks should continue for at least…

Answer 7

…6 to 9 months.

p. 391

Question 8

As a last resort, patients with severe, resistant OCD can be treated with…

Answer 8

…deep brain stimulation.

p. 392

Question 9

What drugs are approved to treat OCD?

Answer 9

4 SSRI’s and 1 TCA -
fluoxetine, fluvoxamine, sertraline, and paroxetine
clomipramine

(p. 392)

Question 10

What is the most common anxiety disorder?

Answer 10

social anxiety disorder

p. 392

Question 11

Evidence for efficacy for treating PTSD is strongest for what 4 drugs?
Of these 4, which 2 are the only ones FDA-approved to treat PTSD?

Answer 11

fluoxetine, paroxetine, and sertraline (SSRI’s)
venlafaxine (SNRI)

paroxetine (Paxil) and sertraline (Zoloft)

(p. 393)

Question 12

Benzodiazepines are used primarily for _____ ________ and ___, whereas SSRIs are used for ___ anxiety disorders.

Answer 12

panic disorder; GAD
all

(p. 393)

Question 13

Busprirone levels can be increased by…

Answer 13

…erythromycin, ketoconazole, and grapefruit juice.

p. 390, 394