Ch 44: Drugs Acting on the Renin-Angiotensin-Aldosterone System

Question 1

What are the 4 families of drugs which affect the RAAS?

Answer 1

1) angiotensin-converting enzyme (ACE) inhibitors
2) angiotensin II receptor blockers (ARBs)
3) direct renin inhibitors (DRIs)
4) aldosterone antagonists

(p. 470)

Question 2

What type of compounds are angiotensin I, II, and III?

Answer 2

small polypeptides

p. 470

Question 3

Angiotensin II participates in all processes regulated by the…
What are its most prominent actions?

Answer 3

…RAAS.
vasoconstriction and stimulation of aldosterone release.

(p. 470)

Question 4

Angiotensin II can cause vasoconstriction indirectly by acting on

1) sympathetic neurons to…
2) the adrenal medulla to…
3) the central nervous system to…

Answer 4

1) …promote norepinephrine release
2) …promote epinephrine release
3) …increase sympathetic outflow to blood vessels

(p. 470)

Question 5

The adrenal cortex is highly sensitive to angiotensin II, and hence angiotensin II can stimulate aldosterone release even when…

Answer 5

….angiotensive levels are too low to induce vasoconstriction.

(p. 470)

Question 6

Aldosterone secretion is enhanced when…

Answer 6

…sodium levels are low and when potassium levels are high.

p. 470

Question 7

Angiotensin II may cause __________ __________ changes in the heart and blood vessels.

Answer 7

pathologic structural

p. 470

Question 8

After being released from the adrenal cortex, aldosterone acts on distal tubules of the kidneys to cause…

Answer 8

…retention of sodium and excretion of potassium and hydrogen.

(p. 470)

Question 9

Renin is produced by _______________ cells of the kidney and undergoes controlled release into the bloodstream, where is cleaves _______________ into ______________.

Answer 9

juxtaglomerular
angiotensinogen
angiotensin I

(p. 472)