Ch 25: Drugs for Muscle Spasm and Spasticity

Question 1

What is the mechanism of action of baclofen?

Answer 1

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Chemically, baclofen is a derivative of the neurotransmitter γ-aminobutyric acid (GABA). It is believed to work by activating (or agonizing) GABA receptors, specifically the GABAB receptors.[16] Its beneficial effects in spasticity result from its actions in the brain and spinal cord. [Wikipedia]

Question 2

The withdrawal from baclofen is similar to that of….

Answer 2

…..alcohol or benzodiazepine withdrawal.

[Wikipedia]