Ch 31: Antipsychotic Agents and Their Use in Schizophrenia

Question 1

First-generation antipsychotics (FGA’s) are also known as…

And second-generation antipsychotics (SGA’s) are also known as…

Answer 1

…conventional antipsychotics
…atypical antipsychotics

(p. 317)

Question 2

All of the FGA’s produce strong…

Answer 2

…blockade of dopamine in the CNS, and thus, cause more EPS than do the SGA’s.

(p. 317)

Question 3

Quetiapine (Seroquel) produces strong blockade of…

Answer 3

…5-HT2 receptors and weaker blockade of D2 receptors. In addition, it blocks H1 receptors and alpha-adrenergic receptors, but does NOT block receptors for acetylcholine.

(p. 329)

Question 4

Quetiapine, though structurally similar to clozapine, does not pose a risk of…

Answer 4

…agranulocytosis.

p. 329

Question 5

Aripiprazole (Abilify) is the first representative of a unique class of antipsychotic drugs referred to as…

Answer 5

…dopamine system stabilizers.

p. 329

Question 6

Unlike so many other antipsychotics, aripiprazole (Abilify) does not…

Answer 6

…prolong the QT interval.

p. 330

Question 7

Because of its unique properties asenapine (Saphris) is well suited for patients who…

Answer 7

1.) have difficulty swallowing or
2.) cannot tolerate the metabolic side effects of some other SGA’s
(Asenapine is formulated as a sublingual tablet and carries a low risk of weight gain, diabetes, or dyslipidemia.)

(p. 330)

Question 8

What is the difference in the MOA of FGA’s vs. SGA’s?

Answer 8

FGA’s cause strong blockade of D2 receptors.
SGA’s cause moderate blockade of D2 receptors and strong blockade of 5-HT2 receptors.

(p. 333)

Question 9

What 2 drugs are used to treat neuroleptic malignant syndrome?

Answer 9

dantrolene and bromocriptine

p. 333