ch 11.4- nervous system Flashcards
neuron
the most basic unit of the nervous
system. It has three parts: the soma (cell body),
dendrites (extensions that receive signals), and the
axon (sends signals out).
axon hillock
Area where the axon is connected
to the cell body. Responsible for the summation
of graded potentials.
myelin sheath
Fatty insulation of the axon that
speeds up action potential propagation by
stopping ion exchange. The myelin sheath is formed by
oligodendrocytes (in the central
nervous system) and
Schwann cells (in the
peripheral nervous system). Thicker myelinated neurons fire signals faster.
nodes of ranvier
Gaps between myelin sheaths
where ion exchange occurs. Propagation of the
action potential occurs here, jumping from gap to
gap (node to node) in a process called saltatory
conduction.
steps of action potential
- At resting potential, the membrane potential of
the neuron is around -70mV and is maintained by Na+/K+ ATPases, which pump three Na+ ions out and two K+
ions in, powered by hydrolysis of one ATP. K +leak channels are also present and help maintain resting potential through passive K+ leakage - When a stimulus causes threshold potential to
be reached (around -55mV in neurons),
voltage-gated Na+ channels open up, letting Na+ in, resulting in depolarization of the neuron. K+ channels are closed. - Next is repolarization of the neuron due to the opening of voltage-gated K+ channels, letting K+ out, and the closing of Na channels. This causes the membrane potential to become less positive
since positive ions are leaving. This is the absolute refractory period: no stimulus can cause an action potential. - When the membrane potential becomes even more negative than the normal resting potential, this is known as hyperpolarization. This results in a relative refractory period being established, during which another action potential can be fired, but it requires a much stronger stimulus.
- The membrane potential returns to normal resting potential through the pumping of Na+ /K+ATPases and K +leak channels.
absolute refractory period
refers to the period after the initiation of the action potential during which another action potential cannot be fired no matter how powerful the stimulus is. It is due to the inactivation of voltage-gated Na+ channels after they open.
the period of depolarization and repolarization
realative refractory period
refers to the period
after the action potential fires during which a stronger
than normal stimulus could cause another action
potential to be fired. (after repolarization)
steps of synaptic transmission
- Action potential reaches the end of the
presynaptic axon, causing voltage-gated
calcium channels to open and letting Ca2+
ions into the neuron. - The Ca2+ ions cause synaptic vesicles to fuse and undergo exocytosis, releasing neurotransmitters into the synapse.
- The neurotransmitters (described in the table on the next page) bind to ligand-gated ion channels on the postsynaptic neuron, producing graded potentials (depolarizations or hyperpolarizations
of the membrane). - These graded potentials summate at the axon hillock and an action potential will fire if the summation of graded potentials is higher than the threshold potential of neurons.
EPSP
An excitatory postsynaptic potential (EPSP) is a
graded potential that depolarizes the membrane.
IPSP
An inhibitory postsynaptic potential (IPSP) is a
graded potential that hyperpolarizes the membrane.
glutamate
Main ENT of the central nervous system
dopamine
Involved in reward motivated behavior
epinephrine
● Postsynaptic NT of the sympathetic nervous system
● Constricts blood vessels and dilates bronchioles
● Increases blood flow to skeletal muscles
● Decreases blood flow to smooth muscles
norepinepherine
Postsynaptic NT of the sympathetic nervous system
Aids epinephrine in the “fight or flight” response
acetylcholine
● Most common NT in the muscular system
● Released from presynaptic motor neurons to signal muscle fibers
● Signals muscle fibers by binding to ligand-gated sodium channels
GABA
Gamma-aminobutyric
acid (GABA)
● Main INT of the central nervous system
glycine
● INT of the central nervous system
seritonin
● INT of the brain
frontal lobe
Known for higher function
processes such as decision making, problem
solving, attention and concentration.
temporal lobe
Known for speech and hearing.
occipital lobe
vision
parietal lobe
Known for spatial perception and
sensation.
cerebellum
located underneath the occipital
lobe and is responsible for the coordination of
movement.
brainstem
midbrain
pons
medulla oblongata
reticular formation
midbrain
Relays senses to other parts of brain.
pons
Relays messages between the forebrain,
cerebellum, and medulla.