ch 11.3- immune system

Question 1

diseases caused by viral pathogens

Answer 1

include HIV, AIDS, influenza, measles, and herpes.

Question 2

leukocytes

Answer 2

white blood cells

Question 3

lymphocytes

Answer 3

White blood cells found mainly in the
lymphatic organs (T cells, B cells, natural killer cells)
that originate from the bone marrow. T cells mature
in the thymus while B cells mature in the bone
marrow.

Question 4

parts of the innate immune system

Answer 4

external immunity: Physical/physiological
barriers preventing pathogen entry. These barriers
include skin, mucous membranes, chemical
secretions, cilia, and symbiotic bacteria.

Internal immunity: Internal defenses activated
by the innate immune system to neutralize
pathogens that have entered. The body’s internal
immunity is composed of the inflammatory
response, complement proteins, and phagocytic
and natural killer cells.

Question 5

mast cells

Answer 5

type of leukocyte responsible for the
first part of the inflammatory response, known as
rally signaling:

Question 6

mast cell function steps

Answer 6

1. Mast cells sit in the tissue in preparation for
   injury.
2. If there is an injury, mast cells will release
   histamine, which dilates blood vessels. This
   increases blood flow and makes vessels more
   permeable to let immune cells into the tissues.
3. Mast cells also release heparin, an anticoagulant
   that prevents blood clotting.

Question 7

inflammatory response

Answer 7

● Swelling: Permeable capillaries result in fluids
leaking into tissues.
● Loss of function: Body part with inflammation
becomes less usable.
● Increased heat: Increased blood flow results in
higher temperature.
● Pain: Throbbing caused by swelling, which puts
continuous pressure on nerve endings.
● Redness: Increased blood flow causes redness of
skin.

A fever can also occur due to the inflammatory
response; this is controlled by the brain and causes a
systemic response to kill pathogens with higher
temperatures.

Question 8

diapedesis

Answer 8

is the process by which cells move from
the capillaries to the tissues in order to fight
pathogens.

Question 9

granulocytes

Answer 9

are cells in the innate immune system
with specific granules in their cytoplasm. The four
types of granulocytes include neutrophils, eosinophils,
basophils, and mast cells.
Mnemonic:
Five main types of leukocytes from highest to lowest
in quantity → Never Let Monkeys Eat Bananas

Question 10

neutrophils

Answer 10

Phagocytes in innate immunity that
make up over half of all leukocytes. Neutrophils
are the most common type of leukocyte found in
blood and are one of the first cells to be recruited
to a site of inflammation.

Question 11

lymphocytes

Answer 11

B cells, T cells, and natural killer
cells. B and T cells are part of adaptive immunity
and must be activated. Natural killer (NK) cells
are part of innate immunity and attack
virally-infected cells + cancerous cells. NK cells
use perforin (create holes) and granzyme
(stimulate apoptosis) to lyse cells. B and T cells
are the most common type of leukocyte found in
lymph.

Question 12

monocytes and macrophages

Answer 12

Phagocytes in innate
immunity. Monocytes are immature form found in
blood vessels and macrophages are mature form
after diapedesis. Can also act as antigen-presenting cells to activate adaptive
immunity.

Question 13

eosinophils

Answer 13

Part of innate immunity and have
granules that can be released to kill pathogens,
especially parasites.

Question 14

basophils

Answer 14

Least numerous leukocyte; contain
granules with histamine (vasodilation) and
heparin (an anticoagulant to prevent blood
clotting). Very similar to mast cells, except
basophils circulate as mature cells while mast
cells circulate as immature cells.

Question 15

histamine function

Answer 15

vasodialation

Question 16

herapin

Answer 16

anticoagulant to prevent blood clotting

Question 17

dendritic cells

Answer 17

part of innate immunity and
scan tissues using pinocytosis (cell drinking) and
phagocytosis (cell eating). They act as
antigen-presenting cells like macrophages,
migrating to the lymph nodes to activate adaptive
immunity.

Question 18

Toll like receptors

Answer 18

Macrophages and dendritic cells use toll-like
receptors (TLR’s) to recognize conserved parts of
microbes. Binding to these receptors triggers
phagocytosis and activates the innate immune
system.

Question 19

interferons

Answer 19

secreted by virally-infected cells and
bind to non-infected cells to prepare them for a virus
attack. Also, interferons help activate dendritic cells.

Question 20

platelets

Answer 20

are also a type of immune cell involved in
activating the innate immune system. These anucleate
cells regulate macrophages and dendritic cells.

Question 21

complement system

Answer 21

is a group of
approximately 30 proteins that aid immune cells in
fighting pathogens. While small, these proteins turn
each other on through the activation of a
complement cascade, producing a large effect.
Upon recognizing a pathogen, a chain reaction of
protease activity is triggered for the proteins to
activate each other.

Question 22

complement protein actions

Answer 22

● Tags antigens for phagocytosis in a process called
opsonization.
● Amplifies inflammatory response (e.g., binds to
mast cells for increased histamine release).
● Forms a membrane attack complex (MAC),
which pokes holes in pathogens and lyses them.

Question 23

antigen and epitope

Answer 23

An antigen is an immunogenic foreign molecule and
is the target of the immune response. The epitope is
the important part of the antigen that is recognized
by the immune cell.

Question 24

major histocompatability complex

Answer 24

The immune system recognizes foreign cells and
antigens using major histocompatibility complex
(MHC) molecules. Once recognized, the immune
system destroys the foreign or infected cell.

Question 25

MHC class I

Answer 25

MHC class I is a surface molecule on all nucleated cells that present intracellular antigens. Each genetically different individual will have a unique MHC I molecule, thus the immune system can use this to distinguish between self and non-self cells.

Question 26

MHC class II

Answer 26

is a surface molecule on antigen-presenting cells (dendritic cells, macrophages) that present extracellular antigens.

Question 27

organ transplants

Answer 27

that have different MHC I may lead to failure and rejection, so immunosuppressants are given to transplant patients. Autoimmune diseases occur when the immune system attacks self MHC I. Identical twins have identical major histocompatibility complex molecules. This allows identical twins to donate organs to each other without the need for immunosuppression (the donated organ cells won’t be marked as foreign).

Question 28

B cells

Answer 28

control antibody-mediated immunity (humoral immunity) by managing the production and release of antibodies. They can also act as antigen-presenting cells.

Question 29

BCRs

Answer 29

B cell receptors (BCRs) are located on B cells and bind to antigen epitopes either free-floating or on APCs. Each B cell has a unique BCR.

Question 30

clonal selection model

Answer 30

describes the development of one type of BCR for every B cell. Through clonal expansion, these B cells divide into either plasma cells (antibody-secreting cells) or memory B cells (to be activated later in case of another attack).

Question 31

memory b cells

Answer 31

survive for a long time and lay dormant until reactivated by the same antigen that triggered the original clonal expansion. They are the key to vaccinations because vaccines cause memory B cell production for later reactivation. After reactivation, memory B cells cause massive antibody production.

Question 32

antibodies

Answer 32

are structurally . identical to BCRs but freely circulate in blood and lymph. They can tag antigens for phagocytosis, neutralize the antigen by coating it, or activate the complement system. Antibodies contain light chains and heavy chains that are linked together by disulfide bonds. In addition, the variable region recognizes different antigens while the constant region is the same for antibodies within the same class.

Question 33

igM

Answer 33

Present in a pentameric form and is the largest antibody. The first antibody to be produced; activates the complement system.

Question 34

igA

Answer 34

Present in a dimeric form and found most abundantly in bodily secretions. Newborns receive passive immunity through breast milk containing IgA.

Question 35

igE

Answer 35

Monomer that is present on basophils and mast cells as antigen receptors. When bound to an allergen, it triggers histamine release and an allergic reaction. Think Ig sneEze.

Question 36

igD

Answer 36

Monomer that we have very little information about. Only small amounts are produced.

Question 37

igG

Answer 37

Monomer that is the most abundant antibody in circulation. Also the only antibody that can cross the placenta to give fetus passive immunity. Helps the complement system to cause opsonization (tags antigens and subsequent phagocytosis). Helps IgM activate the complement system.

Question 38

T cells

Answer 38

control cell-mediated immunity by directly acting on cells instead of sending antibodies out. T cells must bind to antigens presented on APCs (antigen-presenting cells) to be activated. There are two ways antigens may be presented to T cells: 1. MHC I presentation 2. MHC II presentation

Question 39

TCRs

Answer 39

unique just like BCRs, binding only to one type of antigen per T cell. Thus, T cells also undergo clonal selection just like B cells.

Question 40

MHC I presentation

Answer 40

T cells differentiate into cytotoxic T cells (CD8+), which directly kill infected cells through perforin (poke holes) and granzymes (cause apoptosis). However, T cells are different from natural killer cells because they are more specific and require antigen presentation.

Question 41

MHC II presentation

Answer 41

T cells differentiate into helper T cells (CD4+), which release interleukins to boost both innate immunity and adaptive immunity. These interleukins help attract innate immune cells and increase proliferation of other T and B cells.

Question 42

passive immunity

Answer 42

refers to the immunity one organism gains from receiving the antibodies from another organism that already has that immunity. For example, a fetus gains passive immunity through the placenta (IgG) while a newborn gains passive immunity through breast milk (IgA).

Question 43

immuno naive

Answer 43

The fetus and newborn are referred to as immuno-naive because they do not yet have their own active immunity.

Question 44

ative immunity

Answer 44

refers to the immunity an organism gains from being infected once already by a pathogen.

Question 45

artificial immunity

Answer 45

Type of active immunity A vaccination introduces the antigen or pathogen in a deactivated state to stimulate active immunity, which is referred to as artificial immunity in this case and induces memory B and T cell formation.