BIOL 437 Week Five Part 2 Flashcards

1
Q

stable endemicity

A
  • relatively stable incidence of infection or disease

eg. HIV

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2
Q

seasonal endemicity

A
  • some waterborne and respiratory infections

eg. cholera, seasonal influenza

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3
Q

immunizing infections

A
  • recurrent outbreaks with predictable inter epidemic periods
    ex. measles, whooping cough
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4
Q

pathogen characteristics that result in population cycles

A
  • high transmissibility
  • short infectious period
  • transmission-blocking immunity upon recovering
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5
Q

epidemic will not occur until

A

-enough new susceptible individuals are born

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6
Q

inter-epidemic period determined by

A

-birth rate of host
-transmission rate of pathogen
*vaccination reduces number of sustceptible individuals born into a population
>mass vaccination will increase the inter-epidemic period

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7
Q

seasonality

A
  1. Environmentally-forced disease dynamics
  2. Term-time forcing
  3. Behaviourally associated
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8
Q

environmentally forced disease

A

-winter peak in influenza
>time of year depnds on hemisphere
-vector borne infections
-water-borne infections

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9
Q

term-time forcing

A
  • seasonal changes in contacts amon hosts
  • increase contact between school age children
    ex. whooping cough
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10
Q

behaviourally associated

A

-urban-rural seasonal migration
>low contact during wet season: rural
>higher contact rate during dry season: work in urban settings
ex. measles

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11
Q

host diversity

A

-ex. chicken pox
-persistant mechanism within individual host
>dormant in NS, re-emerges when host is an adult as shingles
>respiratory transmission and direct contact with rash

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12
Q

host range

A
  • ex. rabies vaccine
  • wide
  • high affinity for nervous tissue
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13
Q

for infection to spread

A

-average number of new infetions is greater than or equal to old infections

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14
Q

for infection to persist

A

-necessary for at least one infected individual to pass that onward

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15
Q

larger populations

A

-have more opportunity for transmission

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16
Q

critical community size

A
  • population size where transmission of a specific pathogen is a certainty
  • smallest population size for which a given population does NOT go extinct
17
Q

vaccination and effective community size

A

-vaccination reduces it

>reduces number of susceptibles

18
Q

probability of extinction before a major epidemic

A

-equal to rate of recovery divided by transmission rate

19
Q

pathogen microbe interactions

A

-ex. Bordetella: whooping and kennel cough
-whooping cough is only humans
>absence of Type VI secretion system

20
Q

social network

A
  • network of people connected by potential disease transmission events
  • create maps
  • important for contact tracing
  • road maps for spread of infectious disease
21
Q

nodes

22
Q

edges between nodes

A

-potential disease transmission events

23
Q

degree distribution

A
  • of a node is the number of edges it has
  • number of contacts the person has
  • affects R.
24
Q

variance in degree distribution

A

-greatly affected by R.
>some will have more or less contacts than average
-higher R. in high variance network

25
superspreaders
- generate a higher number of secondary cases - particulary long infectious period - shed a large number of the pathogen - large number of contacts
26
rural
-new human pathogens emergence
27
urban
-reserviours for established human pathogens -chain of transmission is strong >increased contact rates >supply of susceptibles
28
island-mainland metapopulation dynamics
- group of location populations connected by infrequent movement between them - susceptible populations increase in smaller communities
29
metapopulations persistance
- larger areas allow for diseases to persist | - spatial waves of spread
30
movement/transportation
- waves of Europeans brought many diseases - wiped out original inhabitants - now we can travel places within hours
31
co-infection consequences
- hosts already infected by one pathogen may be more susceptible to other pathogens - second pathogen may trigger worse infection - interfer with vaccination or treatment * promote super-shedders