Biochemistry Flashcards
2 main renal indications of glomerular function?
GFR
proteinuria
problems with using inulin to measure GFR?
endogenous
not easy to measure
creatinine is secreted into the renal tubule T or F
F
what does creatinine actually measure
marker of muscle protein breakdown
what percentage of creatinine is filtered by the kidney?
90-95% filtered
creatinine tends to overestimate the GFR slightly T or F
T
high creatinine indicates renal disease T or F
T
relationship between creatinine and GFR?
as GFR decreases, creatinine will rise
creatinine is more effectively measured when GFR is very high T or F
F, it changes very minimally when GFR is high
how can creatinine measure high GFR levels more clearly?
measure urine creatinine clearance
eGFR is not great at measuring high GFR levels T or F
T
2 methods of measuring levels of proteinuria?
24hr urine collection
spot sample for protein/creatinine ratio
will microalbuminuria show up on dipstick?
no
what dipstick reading will nephrotic syndrome show up as?
3+
what does microalbuminuria mean?
excretion of albumin in abnormal quantities but still below the limit of protein detection
mciroalbuminuria is the earliest expression of…
diabetic nephropathy
what are plasma cells’ nuclei like?
very prominent
there is less protein in the vascular compartment in nephrotic syndrome T or F
T
what fluid compartment contains more albumin than any other in nephrotic syndrome?
interstitial
cause of stones?
blood loss +/i hypovolaemia
do tubules work in pre-renal or intrinsic renal failure?
pre-renal
will urine sodium be higher in pre-renal or intrinsic renal failure?
intrinsic renal
hgih serum osmolarity = more concentrated urine T or F
T
