BIOCHEM 1 - protein structure and organization Flashcards
Defined by the amino acid sequence
primary structure
structure composed of Rigid planar peptide groups
primary structure
Rotation about the α-carbon
αC – Carbonyl Carbon
Ψ (psi):
Rotation about the α-carbon
αC – N
Ф (phi):
structure with Regular Folding
secondary structure
interaction in secondary structure
Interaction: H-bond between the amide proton and carbonyl oxygen
Spatial arrangement of the atoms in the polypeptide chain
secondary structure
The PRIMARY structure dictates the ____ structure.
Secondary
type of secondary structure having
Intramolecular H-bond
alpha helix
pitch of alpha helix
Pitch: 5.4 Å
aa residue per turn of alpha helix
3.6
Kinds of α – helix
right handed
left handed
where are the R-groups located in alpha helix
outside the helix
type of secondary structure
Intrachain or interchain H-bond
beta pleated sheet
Two types of beta sheet
Parallel pleated sheet
Antiparallel pleated sheet
Other secondary structures
Other helix structures
Random coils
Reverse turns or β bends
Combinations of α and β-strands
supersecondary structures
examples of supersecondary structures
Ex: βαβ unit, αα unit, β-meander and Greek key
– repetitive supersecondary structures
Motif
type of protein structure
Three-dimensonal arrangement
tertiary structure
Important aspect of tertiary structure
arrangement of the side chains of aa residues
Types of protein conformation
Globular proteins
Fibrous proteins
type of protein structure
Spatial arrangement of polypeptide subunits
quaternary structure
Interactions of quaternary structure:
same with tertiary structure
Loss of high level of structural organization of protein
denaturation
It is the sequence of amino acids linked by peptide bonds.
▪ The backbone of a peptide chain or protein.
primary structure
the location of prosthetic groups is shown in this structure
tertiary
structures which repeat over and over in a secondary structure
supersecondary structure
disulfide bonds are most important in this type of structure
tertiary structure
a supersecondary region, often shared by protein, having a specific function
domain
vitamin necessary for hydroxyproline synthesis
C
AA important in holding 3 strands of collagen together
hydroxyproline
fibrous proteins can be composed of either helical or Beta sheet structures, true or false
TRUE
Independently folded regions of proteins
domains
