BIOCHEM 1 - protein structure and organization

Question 1

Defined by the amino acid sequence

Answer 1

primary structure

Question 2

structure composed of Rigid planar peptide groups

Answer 2

primary structure

Question 3

Rotation about the α-carbon

αC – Carbonyl Carbon

Answer 3

Ψ (psi):

Question 4

Rotation about the α-carbon

αC – N

Answer 4

Ф (phi):

Question 5

structure with Regular Folding

Answer 5

secondary structure

Question 6

interaction in secondary structure

Answer 6

Interaction: H-bond between the amide proton and carbonyl oxygen

Question 7

Spatial arrangement of the atoms in the polypeptide chain

Answer 7

secondary structure

Question 8

The PRIMARY structure dictates the ____ structure.

Answer 8

Secondary

Question 9

type of secondary structure having

Intramolecular H-bond

Answer 9

alpha helix

Question 10

pitch of alpha helix

Answer 10

Pitch: 5.4 Å

Question 11

aa residue per turn of alpha helix

Answer 11

3.6

Question 12

Kinds of α – helix

Answer 12

right handed

left handed

Question 13

where are the R-groups located in alpha helix

Answer 13

outside the helix

Question 14

type of secondary structure

Intrachain or interchain H-bond

Answer 14

beta pleated sheet

Question 15

Two types of beta sheet

Answer 15

Parallel pleated sheet

Antiparallel pleated sheet

Question 16

Other secondary structures

Answer 16

Other helix structures
Random coils
Reverse turns or β bends

Question 17

Combinations of α and β-strands

Answer 17

supersecondary structures

Question 18

examples of supersecondary structures

Answer 18

Ex: βαβ unit, αα unit, β-meander and Greek key

Question 19

– repetitive supersecondary structures

Answer 19

Motif

Question 20

type of protein structure

Three-dimensonal arrangement

Answer 20

tertiary structure

Question 21

Important aspect of tertiary structure

Answer 21

arrangement of the side chains of aa residues

Question 22

Types of protein conformation

Answer 22

Globular proteins

Fibrous proteins

Question 23

type of protein structure

Spatial arrangement of polypeptide subunits

Answer 23

quaternary structure

Question 24

Interactions of quaternary structure:

Answer 24

same with tertiary structure

Question 25

Loss of high level of structural organization of protein

Answer 25

denaturation

Question 26

It is the sequence of amino acids linked by peptide bonds.

▪ The backbone of a peptide chain or protein.

Answer 26

primary structure

Question 27

the location of prosthetic groups is shown in this structure

Answer 27

tertiary

Question 28

structures which repeat over and over in a secondary structure

Answer 28

supersecondary structure

Question 29

disulfide bonds are most important in this type of structure

Answer 29

tertiary structure

Question 30

a supersecondary region, often shared by protein, having a specific function

Answer 30

domain

Question 31

vitamin necessary for hydroxyproline synthesis

Answer 31

C

Question 32

AA important in holding 3 strands of collagen together

Answer 32

hydroxyproline

Question 33

fibrous proteins can be composed of either helical or Beta sheet structures, true or false

Answer 33

TRUE

Question 34

Independently folded regions of proteins

Answer 34

domains