B12 - Kidneys Flashcards
kidney function
homeostasis in water balance of body
kidneys if body is short on water
-conserves water content
-urine is little and concentrated
kidneys if there is lots of water
-produces lots of dilute urine to remove excess
mineral ions is removed by
removed by sweat
-excess removed by urine
Process of kidneys: filtration
-filters blood
-glucose, mineral ions, urea, water are filtered out
what isn’t filtered out of blood in kidneys
-blood cells and proteins are too large
Process of kidneys: selective reabsorption
all glucose is reabsorbed into blood by diffusion and active transport
Process of kidneys: selective reabsorption/ water regulation
-amount of water/mineral ions reabsorbed varies
-controlled by negative feedback
-ensures water balance in blood is kept within narrow range
kidneys tubules
-inside nephrons
-millions make up kidneys
-selective reabsorption and removal of urea occurs here
ADH
-secreted by pituitary gland
-negative feedback maintains water content in blood
How is concentration of solutes in blood plasma detected
receptor cells in brain
high concentration of solutes in blood
-ADH is released
-tubules become more permeable
-more water is reabsorbed
-concentrated urine
-solute level returns to normal
low concentration of solutes or dilute blood
-ADH is inhibited
-tubules less permeable
-less reabsorption
- dilute urine
How can kidneys become damages
-infection
trauma
-genetics
problems caused by faulty kidney
-urea builds up and mineral ions
-water balance of body isn’t maintained
-cells damaged by osmosis
dialysis
function of kidney is carried out artificially
kidney transplant
-failed kidneys are replaced by healthy ones
Dialysis machine process
-blood leaves body
-flows between partially permeable membrane alongside dialysis fluid
dialysis fluid
-contains same concentration of useful substance as healthy person
purpose of dialysis fluid
restores concentrations of substances to normal levels
-ensures not net movement of glucose out of blood
mineral ion sand dialysis fluid
-excess mineral ions diffuse out of blood
-blood plasma has normal mineral ion levels
urea and dialysis fluid
-dialysis fluid contains no urea
-urea from blood diffuses out of blood = steep concentration gradient
diffusion in dialysis
-entirely depends on diffusion
-maintain concentration gradient
-maintained by flow of fluid
Cons of dialysis
-strictly controlled diet
-regular long visits in hospital
-short time periods with good health - start to feel sick nearing next session
-eventually damages body
Kidney transplants: reason for rejection
antigens are diff
-antibodies may attack antigens
-causes destruction of donor kidney
antigens
proteins on cell surface
Ways of reducing rejection of kidney transplant
-matching antigens very accurately
-immunosuppressant drugs
cons of kidney transplant
-rejection
-won’t last forever and will need to be replaced
-must take immunosuppressants for rest of life
-regular checks for rejection
-very hard to find
problem with immunosuppressant drugs
-weakens immune system to diseases as well
pros of dialysis
-readily available
pros of kidney transplant
-less expensive
-free from restrictions (no strict diet)