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Renal > Adverse Drug Reactions > Flashcards

Adverse Drug Reactions Flashcards

1
Q

What is type A ADR?

A

augmented pharmacologic effects- dose dependent and predictable

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2
Q

What is type B ADR?

A

bizarre effects which are dose independent and unpredictable

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3
Q

What is type C ADR?

A

chronic effects

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4
Q

What is type D ADR?

A

delayed effects

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5
Q

What is type E ADR?

A

end of treatment effects

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6
Q

What is type F ADR?

A

failure of therapy

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7
Q

What are the stages of ADR ddetection?

A

drug development phase; clinical trials; post-marketing surveillance

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8
Q

What drugs can cause AIN/tubular necrosis?

A

gentamicin; sulphonamides; aspirin

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9
Q

What drug can cause retroperitoneal fibrosis?

A

methysergide

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10
Q

What drug can cause bone marrow aplasia?

A

chloramphenicol

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11
Q

What drug can cause hepatic necrosis?

A

halothane

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12
Q

When do type C ADR occur?

A

after prolonged therapy with a drug

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13
Q

What are examples of type C ADR?

A

steroids and cushings; beta-blockers and DM; NSAIDs and HT

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14
Q

what are type D ADR?

A

ADR that are remote from treatment and often many years after stopping

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15
Q

What are the main types of type D ADR?

A

teratogenic/carcinogenic effects

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16
Q

When do type E ADR occur?

A

when drugs are abruptly withdrawn

17
Q

What are examples of type E ADR?

A

beta blocker and angina; steroid withdrawal and Addisonian crisis

18
Q

What is the problem with macrolides and statins being prescribed together?

A

macrolides interfere with breakdown of statin so increased statin levels will give more statin SE

19
Q

How do ACEi interfere with SUs?

A

increase hypoglycaemic effect

20
Q

What are patients with Parkinson’s more at risk with in terms of drug SE?

A

have increased risk of drug induced confusion

21
Q

How can decongestants affect BPH?

A

have anticholinergic actions so cause urinary retention

22
Q

What foods can interact with warfarin?

A

apples; chickpears; spinach; nuts; kiwi and broccoli

Renal (33 decks)

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